Pre_GI Gene

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Host: NC_007384 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007384:1696831 Shigella sonnei Ss046, complete genome

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic in China in the 1950s. A leading cause of dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. This extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
16986071699227621IS2 ORF2QuickGO ontologyBLASTP
16992551699461207IS600 ORF2QuickGO ontologyBLASTP
16994701699694225IS600 ORF2QuickGO ontologyBLASTP
16999261700405480IS21 ORF1QuickGO ontologyBLASTP
17004051701202798IS21 ORF2QuickGO ontologyBLASTP
17012501701519270IS2 ORF2QuickGO ontologyBLASTP
17017901702704915putative adhesinQuickGO ontologyBLASTP
170303817053172280putative oxidoreductase major subunitQuickGO ontologyBLASTP
17055651705762198hypothetical proteinBLASTP
17058371706598762putative ARAC-type regulatory proteinQuickGO ontologyBLASTP
170699917086811683putative sulfataseQuickGO ontologyBLASTP
170871817098901173putative enzymeQuickGO ontologyBLASTP
171018717118721686putative ATP-binding component of a transport systemQuickGO ontologyBLASTP
171191317132591347IS4 ORFQuickGO ontologyBLASTP
171334917157212373hypothetical proteinBLASTP
171576617185612796putative peptidaseQuickGO ontologyBLASTP