Pre_GI Gene

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Host: NC_007322 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007322:1 Bacillus anthracis str. 'Ames Ancestor' plasmid pXO1, complete

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
46255493hypothetical proteinBLASTP
9961109114hypothetical proteinBLASTP
11271765639hypothetical proteinBLASTP
17822165384hypothetical proteinBLASTP
22912875585hypothetical proteinBLASTP
28953473579hypothetical proteinBLASTP
35244111588hypothetical proteinBLASTP
41594788630hypothetical proteinBLASTP
51245837714hypothetical proteinBLASTP
58546561708hypothetical proteinBLASTP
667884861809reverse transcriptaseendonuclease protein pxo1-07QuickGO ontologyBLASTP
8991908393hypothetical proteinBLASTP
9090116752586hypothetical proteinBLASTP
1174711974228hypothetical proteinBLASTP
11990130811092hypothetical proteinBLASTP
1318413327144hypothetical proteinBLASTP
1334313756414hypothetical proteinBLASTP
1437115063693hypothetical proteinBLASTP
15174191363963hypothetical proteinBLASTP
19200208941695hypothetical proteinBLASTP
2105321172120hypothetical proteinBLASTP
2127921713435hypothetical proteinBLASTP