Pre_GI Gene

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Host: NC_005945 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005945:754517 Bacillus anthracis str. Sterne, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
753768754520753ABC transporter permease protein putativeQuickGO ontologyBLASTP
7545177555181002ABC transporter substrate-binding protein putativeQuickGO ontologyBLASTP
755529756149621transcriptional regulator TenIQuickGO ontologyBLASTP
7561427572511110glycine oxidaseQuickGO ontologyBLASTP
757267757470204sulfur carrier protein ThiSQuickGO ontologyBLASTP
757467758243777thiazole synthaseQuickGO ontologyBLASTP
7582367592551020molybdopterin biosynthesis protein MoeBQuickGO ontologyBLASTP
759271760083813phosphomethylpyrimidine kinaseQuickGO ontologyBLASTP
760525760794270hypothetical protein
760722760904183hypothetical protein
7617497634161668potassium-transporting ATPase subunit AQuickGO ontologyBLASTP
7634277655202094potassium-transporting ATPase subunit BQuickGO ontologyBLASTP
765537766118582potassium-transporting ATPase C subunitQuickGO ontologyBLASTP
7661817673291149sensor histidine kinase KdpDQuickGO ontologyBLASTP
7673547685351182major facilitator family transporterQuickGO ontologyBLASTP
768676769137462transcriptional regulator MarR familyQuickGO ontologyBLASTP
769266770120855phospholipase putativeQuickGO ontologyBLASTP
770137770451315hypothetical protein
7705497718501302xanthineuracil permease family proteinQuickGO ontologyBLASTP
772052772918867short chain dehydrogenaseQuickGO ontologyBLASTP
772985773221237hypothetical proteinBLASTP
773347773745399hypothetical protein