Pre_GI Gene

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Host: NC_005945 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005945:3636321 Bacillus anthracis str. Sterne, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
363632136375831263membrane-associated zinc metalloprotease putativeQuickGO ontologyBLASTP
3637594363873611431-deoxy-D-xylulose 5-phosphate reductoisomeraseQuickGO ontologyBLASTP
36387603639551792phosphatidate cytidylyltransferaseQuickGO ontologyBLASTP
36395693640345777undecaprenyl diphosphate synthaseQuickGO ontologyBLASTP
36404313640988558ribosome releasing factorQuickGO ontologyBLASTP
36409913641713723uridylate kinaseQuickGO ontologyBLASTP
36417803642667888elongation factor TsQuickGO ontologyBLASTP
3642771364347270230S ribosomal protein S2QuickGO ontologyBLASTP
36438223644601780transcriptional repressor CodYQuickGO ontologyBLASTP
364467936460701392ATP-dependent protease ATP-binding subunitQuickGO ontologyBLASTP
36460933646635543ATP-dependent protease peptidase subunitQuickGO ontologyBLASTP
36466783647577900tyrosine recombinaseQuickGO ontologyBLASTP
364764336489471305glucose-inhibited division protein AQuickGO ontologyBLASTP
364899836510762079DNA topoisomerase IQuickGO ontologyBLASTP
36514243652089666nucleotide-binding SMF proteinQuickGO ontologyBLASTP
36521773653079903succinyl-CoA synthetase alpha subunitQuickGO ontologyBLASTP
365310036542601161succinyl-CoA synthetase subunit betaQuickGO ontologyBLASTP
36544543655227774ribonuclease HIIQuickGO ontologyBLASTP
36552793656169891GTPase family proteinQuickGO ontologyBLASTP
36561903656741552signal peptidase I SQuickGO ontologyBLASTP
3656843365718734550S ribosomal protein L19QuickGO ontologyBLASTP
36573343658068735tRNA guanine-N1--methyltransferaseQuickGO ontologyBLASTP
3658068365858351616S rRNA-processing proteinQuickGO ontologyBLASTP
36587043658931228KH domain proteinQuickGO ontologyBLASTP
3658946365921827330S ribosomal protein S16QuickGO ontologyBLASTP
365931936606681350signal recognition particle proteinQuickGO ontologyBLASTP
36606813661013333hypothetical proteinBLASTP
36611463662135990signal recognition particle-docking protein FtsYQuickGO ontologyBLASTP
366215136657203570chromosome segregation SMC proteinQuickGO ontologyBLASTP
36658673666604738ribonuclease IIIQuickGO ontologyBLASTP
36666633666896234acyl carrier proteinQuickGO ontologyBLASTP
366696636677067413-ketoacyl-acyl-carrier-protein reductaseQuickGO ontologyBLASTP
36677063668650945acyl-carrier-protein S-malonyltransferaseQuickGO ontologyBLASTP
36686653669657993fatty acidphospholipid synthesis proteinQuickGO ontologyBLASTP
36696543670406753transcriptional regulator of fatty acid biosynthesisQuickGO ontologyBLASTP
367033636723842049ATP-dependent DNA helicase RecGQuickGO ontologyBLASTP
367267436743501677phosphatase putativeQuickGO ontologyBLASTP
36743733674735363hypothetical proteinBLASTP
36751143675302189ribosomal protein L28QuickGO ontologyBLASTP
36755223676163642hypothetical proteinBLASTP
36763023676946645ribulose-phosphate 3-epimeraseQuickGO ontologyBLASTP
36769493677830882ribosome-associated GTPaseQuickGO ontologyBLASTP
367809936800721974serinethreonine protein kinaseQuickGO ontologyBLASTP