Pre_GI Gene

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Host: NC_004631 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004631:4300457 Salmonella enterica subsp. enterica serovar Typhi Ty2, complete

Host Lineage: Salmonella enterica; Salmonella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This pathogenic strain of Salmonella typhi was isolated in the early 1970s. It contains no multidrug resistance plasmids and has been used for vaccine development. This serovar is a human-specific organism that causes the life-threatening illness Typhoid fever which is acquired by coming into contact with contaminated food or water. Annually, 17 million people are infected, with 600,000 fatalities, mostly in developing countries. It contains multiple fimbrial operons that may be used to create extracellular appendages for attachment and entry into host intestinal epithelial cells. Causes enteric infections. This group of Enterobactericiae have pathogenic characteristics and are one of the most common causes of enteric infections (food poisoning) worldwide. They were named after the scientist Dr. Daniel Salmon who isolated the first organism, Salmonella choleraesuis, from the intestine of a pig. The presence of several pathogenicity islands (PAIs) that encode various virulence factors allows Salmonella spp. to colonize and infect host organisms. There are two important PAIs, Salmonella pathogenicity island 1 and 2 (SPI-1 and SPI-2) that encode two different type III secretion systems for the delivery of effector molecules into the host cell that result in internalization of the bacteria which then leads to systemic spread.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
43004574301170714class B acid phosphatase precursorQuickGO ontologyBLASTP
43012994301715417hypothetical proteinBLASTP
43017184302074357hypothetical proteinBLASTP
43020754302413339hypothetical proteinBLASTP
43024004302855456putative lipoproteinQuickGO ontologyBLASTP
430298743058122826excinuclease ABC subunit AQuickGO ontologyBLASTP
43060604306590531single-strand DNA-binding proteinQuickGO ontologyBLASTP
43076434308275633hypothetical proteinBLASTP
430827243096601389putative integral membrane proteinQuickGO ontologyBLASTP
430965043109571308putative type-I secretion proteinQuickGO ontologyBLASTP
431095443122311278putative type-I secretion proteinQuickGO ontologyBLASTP
431224843220999852large repetitive proteinQuickGO ontologyBLASTP
432215743289276771large repetitive proteinQuickGO ontologyBLASTP