Pre_GI Gene

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Host: NC_004557 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004557:1 Clostridium tetani E88, complete genome

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
123042304negative regulator of genetic competence mecBQuickGO ontologyBLASTP
248739231437putative cardiolipin synthetase 2QuickGO ontologyBLASTP
40274548522DNA polymerase bacteriophage-typeQuickGO ontologyBLASTP
45845144561hypothetical proteinBLASTP
5249532476tRNA-LysQuickGO ontologyBLASTP
53405427885S ribosomal RNAQuickGO ontologyBLASTP
56068450284523S ribosomal RNAQuickGO ontologyBLASTP
59386594657hypothetical proteinBLASTP
871510223150916S ribosomal RNAQuickGO ontologyBLASTP
1075311397645hypothetical proteinBLASTP