Pre_GI Gene

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Host: NC_004088 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004088:3382148 Yersinia pestis KIM, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
338214833834281281citrate synthaseQuickGO ontologyBLASTP
33835363384114579heat shock proteinQuickGO ontologyBLASTP
33842383385119882inorganic polyphosphateATP-NAD kinaseQuickGO ontologyBLASTP
338509833868671770DNA repair proteinQuickGO ontologyBLASTP
33869723387322351small membrane protein AQuickGO ontologyBLASTP
33874723387756285hypothetical proteinBLASTP
33877493388285537hypothetical proteinBLASTP
33883323388826495SsrA-binding proteinQuickGO ontologyBLASTP
33894103389919510transposaseQuickGO ontologyBLASTP
339011033913421233prophage CP4-57 integraseQuickGO ontologyBLASTP
339142133925091089hypothetical proteinBLASTP
339256033940501491hypothetical proteinBLASTP
33951143395404291hypothetical proteinBLASTP
33954173396313897hypothetical proteinBLASTP
33965063397048543hypothetical proteinBLASTP
33970113398000990hypothetical proteinBLASTP
339799133990851095hypothetical proteinBLASTP
33994343399754321hypothetical proteinBLASTP
340067634016981023transposaseQuickGO ontologyBLASTP
34016953402477783transposaseIS proteinQuickGO ontologyBLASTP
34025283402767240hypothetical proteinBLASTP
340320834045661359permeaseQuickGO ontologyBLASTP
3404626340469974tRNA-AspQuickGO ontologyBLASTP
34048123405576765DNA polymerase III subunit epsilonQuickGO ontologyBLASTP
34056463406110465ribonuclease HQuickGO ontologyBLASTP