Pre_GI Gene

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Host: NC_003888 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003888:2305901 Streptomyces coelicolor A3(2), complete genome

Host Lineage: Streptomyces coelicolor; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Well-studied antiobiotic-producing bacterium. These bacteria are widely distributed in nature, especially in the soil. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This bacterium is a soil-dwelling filamentous organism responsible for producing more than half of the known natural antibiotics. It is a well-studied species of Streptomyces and genetically is the best known representative.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
230590123071991299glycerate kinaseQuickGO ontologyBLASTP
230707623085061431aminotransferaseQuickGO ontologyBLASTP
230885123099151065anthranilate phosphoribosyltransferaseQuickGO ontologyBLASTP
231004723116841638cytochrome B subunitQuickGO ontologyBLASTP
231168123127421062Rieske iron-sulfur proteinQuickGO ontologyBLASTP
23127392313548810cytochrome C heme-binding subunitQuickGO ontologyBLASTP
23136232314243621cytochrome c oxidase subunit IIIQuickGO ontologyBLASTP
23144532314854402response regulatorQuickGO ontologyBLASTP
231494223162161275secreted proteinQuickGO ontologyBLASTP
23163632316761399integral membrane proteinQuickGO ontologyBLASTP
231675823184941737cytochrome c oxidase subunit IQuickGO ontologyBLASTP
23184912319450960cytochrome c oxidase subunit IIQuickGO ontologyBLASTP
231977723211591383aminotransferaseQuickGO ontologyBLASTP
232128223222981017kinaseQuickGO ontologyBLASTP
23223892322598210hypothetical proteinBLASTP
232271523242651551large membrane proteinQuickGO ontologyBLASTP
23243682324724357hypothetical proteinBLASTP
232506423262481185quinolinate synthetaseQuickGO ontologyBLASTP
232632723294523126integral membrane efflux proteinQuickGO ontologyBLASTP