Pre_GI Gene

Some Help

Host: NC_003143 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003143:2137945 Yersinia pestis CO92, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
21379452138526582hypothetical proteinBLASTP
21385322138696165hypothetical proteinBLASTP
21387152138996282putative transcriptional regulatorQuickGO ontologyBLASTP
21390402139594555hypothetical proteinBLASTP
21396022139967366hypothetical proteinBLASTP
214084021428612022pesticinyersiniabactin receptor proteinQuickGO ontologyBLASTP
214299221445691578yersiniabactin siderophore biosynthetic proteinQuickGO ontologyBLASTP
21445732145376804yersiniabactin biosynthetic protein YbtTQuickGO ontologyBLASTP
214537321464731101yersiniabactin biosynthetic protein YbtUQuickGO ontologyBLASTP
214647021559619492yersiniabactin biosynthetic proteinQuickGO ontologyBLASTP
215604921621566108yersiniabactin biosynthetic proteinQuickGO ontologyBLASTP
21623472163306960transcriptional regulator YbtAQuickGO ontologyBLASTP
216347321652751803lipoprotein inner membrane ABC-transporterQuickGO ontologyBLASTP
216526221670641803inner membrane ABC-transporter YbtQQuickGO ontologyBLASTP
216705721683371281putative signal transducerQuickGO ontologyBLASTP
216836521696691305anthranilate synthase component IQuickGO ontologyBLASTP
216986321711251263integraseQuickGO ontologyBLASTP
2171287217136276tRNA-AsnQuickGO ontologyBLASTP
21716652172405741probable pili assembly chaperoneQuickGO ontologyBLASTP
217240221737511350hypothetical proteinBLASTP
217376721763582592probable fimbrial usher proteinQuickGO ontologyBLASTP
21764072177051645probable pili assembly chaperoneQuickGO ontologyBLASTP