Pre_GI Gene

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Host: NC_003143 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003143:1441211 Yersinia pestis CO92, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
144121114424041194mannonate dehydrataseQuickGO ontologyBLASTP
14425441443116573elongation factor PQuickGO ontologyBLASTP
144322014444641245putative tryptophan-specific transport proteinQuickGO ontologyBLASTP
14448391445093255hypothetical proteinBLASTP
14451621445977816putative short chain oxidoreductaseQuickGO ontologyBLASTP
14459881446953966putative D-isomer specific 2-hydroxyacid dehydrogenase family proteinQuickGO ontologyBLASTP
144695014480921143hypothetical proteinBLASTP
144844414499401497putative aldehyde dehydrogenaseQuickGO ontologyBLASTP
144994414514971554putative carbohydrate kinaseQuickGO ontologyBLASTP
14515171452227711putative ribose 5-phosphate isomeraseQuickGO ontologyBLASTP
145235914534471089putative periplasmic carbohydrate-binding transport proteinQuickGO ontologyBLASTP
145355614551301575putative ABC transport ATP-binding subunitQuickGO ontologyBLASTP
14551661456164999putative ABC transport integral membrane subunitQuickGO ontologyBLASTP
14562771456798522putative Mut family proteinQuickGO ontologyBLASTP
145699414581271134hypothetical proteinBLASTP
145812414590629391-phosphofructokinaseQuickGO ontologyBLASTP
145907714607771701PTS system fructose-specific IIBC componentQuickGO ontologyBLASTP
14611021461746645putative regulatory proteinQuickGO ontologyBLASTP
14617431462231489hypothetical proteinBLASTP