Pre_GI Gene

Some Help

Host: NC_017160 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017160:1628500 Yersinia pestis D182038 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.


StartEndLengthCDS descriptionQuickGO ontologyBLASTP
16286541629070417hypothetical proteinBLASTP
16291791629496318hypothetical proteinBLASTP
162955716307471191hypothetical proteinBLASTP
16311711631500330sulfite reductaseQuickGO ontologyBLASTP
16329051633261357hypothetical proteinBLASTP
163356116347121152hypothetical proteinBLASTP
163514616375632418putative oxidoreductaseQuickGO ontologyBLASTP
16377171638463747putative short chain dehydrogenaseQuickGO ontologyBLASTP
16396761640200525myristoyl-acyl carrier dehydrataseQuickGO ontologyBLASTP
164019016414731284putative beta-ketoacyl-acyl-carrier-protein synthaseQuickGO ontologyBLASTP
16414751642212738short chain dehydrogenasereductase family oxidoreductaseQuickGO ontologyBLASTP
164222816434661239putative hydroxymethylglutaryl-coenzyme A synthaseQuickGO ontologyBLASTP
16434591644178720enoyl-CoA hydrataseQuickGO ontologyBLASTP
16441801644932753enoyl-CoA hydrataseQuickGO ontologyBLASTP
16449351645723789putative short chain dehydrogenaseQuickGO ontologyBLASTP
16459181646250333hypothetical proteinBLASTP
16466351647483849putative acyl transferaseQuickGO ontologyBLASTP
16484721648972501hypothetical proteinBLASTP
164902116505651545hypothetical proteinBLASTP
165068216519291248hypothetical proteinBLASTP
16519261652534609membrane proteinQuickGO ontologyBLASTP
165261116543471737putative OmpA-family membrane proteinQuickGO ontologyBLASTP
16543511654842492hypothetical proteinBLASTP
165526016567831524putative ATPase subunit of ATP-dependent proteaseQuickGO ontologyBLASTP
165678016579041125Clp ATPaseQuickGO ontologyBLASTP
165790716602552349hypothetical proteinBLASTP
166027116625682298hypothetical proteinBLASTP
16625551663322768hypothetical proteinBLASTP
16637591664115357insertion sequence proteinQuickGO ontologyBLASTP
16647231665358636hypothetical proteinBLASTP
166537416676742301putative kinaseQuickGO ontologyBLASTP
16676711668444774hypothetical proteinBLASTP