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Query: NC_018939:1583653 Helicobacter pylori 26695 chromosome, complete genome

Start: 1583653, End: 1605799, Length: 22147

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_009922:24874922487492251068223191Alkaliphilus oremlandii OhILAs, complete genome1e-1179.8BLASTN svgBLASTP svg
NC_003912:30265*302655431024046Campylobacter jejuni RM1221, complete genome2e-1695.6BLASTN svgBLASTP svg
NC_008787:31999*319995922327225Campylobacter jejuni subsp. jejuni 81-176, complete genome2e-1075.8BLASTN svgBLASTP svg
NC_009839:30409*304095668526277Campylobacter jejuni subsp. jejuni 81116, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_014802:27857*278575874230886Campylobacter jejuni subsp. jejuni ICDCCJ07001 chromosome, complete3e-1281.8BLASTN svgBLASTP svg
NC_002163:29726*297265531925594Campylobacter jejuni subsp. jejuni NCTC 11168, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_012039:1399699*1399699142559925901Campylobacter lari RM2100, complete genome7e-1073.8BLASTN svgBLASTP svg
NC_000915:15839671583967160577621810Helicobacter pylori 26695, complete genome09995BLASTN svgBLASTP svg
NC_011498:15718401571840159084819009Helicobacter pylori P12, complete genome03435BLASTN svgBLASTP svg
NC_015160:26646132664613268809923487Odoribacter splanchnicus DSM 20712 chromosome, complete genome1e-0869.9BLASTN svgBLASTP svg