Pre_GI: BLASTP Hits

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Query: NC_017372:902043:904957 Helicobacter pylori India7 chromosome, complete genome

Start: 904957, End: 908334, Length: 3378

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017372:1212000:1226126122612612319815856Helicobacter pylori India7 chromosome, complete genomehypothetical protein01305
NC_000921:1147394:1157436115743611609003465Helicobacter pylori J99, complete genomehypothetical protein01205
NC_017358:182854:2014592014592072995841Helicobacter pylori Cuz20 chromosome, complete genomehypothetical protein01015
NC_008229:1397361:1405053140505314102725220Helicobacter acinonychis str. Sheeba, complete genomeconserved hypothetical mosaic CUP0956/HP1116/jhp1044-like protein0944
NC_014256:636000:6468596468596484151557Helicobacter pylori B8 chromosome, complete genomehypothetical protein0787
NC_017368:468934:471964471964472617654Helicobacter pylori F16, complete genomehypothetical protein6e-118426
NC_010698:870312:874327874327874701375Helicobacter pylori Shi470, complete genomehypothetical protein2e-55218
NC_014256:636000:645872645872646768897Helicobacter pylori B8 chromosome, complete genomehypothetical protein4e-50201
NC_017372:902043:908309908309908737429Helicobacter pylori India7 chromosome, complete genomehypothetical protein2e-48195
NC_003912:510498:5227185227185264193702Campylobacter jejuni RM1221, complete genomehypothetical protein9e-22106
NC_009707:281000:2909132909132945783666Campylobacter jejuni subsp. doylei 269.97 chromosome, completehypothetical protein5e-1894
NC_009707:980000:9921949921949959283735Campylobacter jejuni subsp. doylei 269.97 chromosome, complete9e-1376.6
NC_009715:1829978:1846407184640718495533147Campylobacter curvus 525.92 chromosome, complete genomehypothetical protein6e-1067.4