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Query: NC_017328:303987:324275 Shigella flexneri 2002017 chromosome, complete genome

Start: 324275, End: 324793, Length: 519

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_006905:368942:390384390384390902519Salmonella enterica subsp. enterica serovar Choleraesuis strgp23-like protein2e-88324
NC_012125:1330066:135198613519861352177192Salmonella enterica subsp. enterica serovar Paratyphi C straingp23-like protein3e-23107
NC_011205:609464:634411634411634548138Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853gp237e-1476.6
NC_009053:553298:572867572867573379513Actinobacillus pleuropneumoniae L20, complete genomehypothetical protein7e-1270.1
NC_010658:1933605:195794919579491958329381Shigella boydii CDC 3083-94, complete genomephage antitermination Q type 1 family2e-0652.4
NC_011415:2153243:215451321545132154896384Escherichia coli SE11 chromosome, complete genomeputative phage antitermination protein2e-0652
NC_012947:2189533:219279821927982193175378Escherichia coli 'BL21-Gold(DE3)pLysS AG' chromosome, completeantitermination Q family protein9e-0649.7
NC_009800:1657550:167335316733531673730378Escherichia coli HS, complete genomephage antitermination Q type 1 family9e-0649.7