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Query: NC_017328:303987:324090 Shigella flexneri 2002017 chromosome, complete genome

Start: 324090, End: 324278, Length: 189

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011147:2496808:250585525058552506043189Salmonella enterica subsp. enterica serovar Paratyphi A strhypothetical protein3e-28123
NC_006511:2501500:251031925103192510507189Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCChypothetical protein3e-28123
NC_009800:289000:307541307541307729189Escherichia coli HS, complete genomephage NinH protein3e-28123
NC_013850:1887556:190894019089401909137198Klebsiella variicola At-22 chromosome, complete genomeNinH family protein4e-1683.6
NC_016860:364981:385479385479385682204Salmonella enterica subsp. enterica serovar Typhimurium strhypothetical protein2e-1478.2
NC_011083:374000:391696391696391899204Salmonella enterica subsp. enterica serovar Heidelberg str. SL476,hypothetical protein2e-1477.4
NC_013364:3312379:333294533329453333139195Escherichia coli O111:H- str. 11128, complete genomehypothetical protein2e-1374.3
NC_014306:3524980:356314135631413563347207Erwinia billingiae Eb661, complete genomephage NinH protein7e-1372.4
NC_013361:3287671:328893432889343289140207Escherichia coli O26:H11 str. 11368 chromosome, complete genomehypothetical protein1e-1271.6
NC_012759:4132527:414864141486414148847207Escherichia coli BW2952 chromosome, complete genomeProtein ninH1e-1271.6
NC_011740:2072173:210345021034502103656207Escherichia fergusonii ATCC 35469, complete genomeconserved hypothetical protein, Protein ninH from phage origin1e-1271.6
NC_012125:1330066:135132913513291351502174Salmonella enterica subsp. enterica serovar Paratyphi C strainNinH2e-1064.3
NC_013282:1200993:122288912228891223080192Cronobacter turicensis, complete genomeProtein ninH6e-0856.2