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Query: NC_017328:303987:318413 Shigella flexneri 2002017 chromosome, complete genome

Start: 318413, End: 318628, Length: 216

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_004431:1401681:141304014130401413420381Escherichia coli CFT073, complete genomehypothetical protein5e-37152
NC_011742:1177946:119185811918581192244387Escherichia coli S88 chromosome, complete genomerepressor protein8e-37152
NC_013364:2645438:265199426519942652209216Escherichia coli O111:H- str. 11128, complete genomeputative antirepressor protein Cro3e-36150
NC_011601:1039500:105254110525411052756216Escherichia coli O127:H6 str. E2348/69 chromosome, complete genomeantirepressor protein3e-36150
NC_008563:1175035:118837111883711188655285Escherichia coli APEC O1, complete genomehypothetical protein3e-36150
NC_013941:975353:989930989930990214285Escherichia coli O55:H7 str. CB9615 chromosome, complete genomehypothetical protein3e-36150
NC_014306:3524980:356761535676153567845231Erwinia billingiae Eb661, complete genomePhage Cro protein8e-1992.4
NC_013850:1887556:190073119007311900940210Klebsiella variicola At-22 chromosome, complete genometranscriptional regulator, XRE family7e-1165.9
NC_003198:1908238:192456419245641924806243Salmonella enterica subsp. enterica serovar Typhi str. CT18,putative cro repressor8e-1165.9
NC_016612:3803130:381468138146813814902222Klebsiella oxytoca KCTC 1686 chromosome, complete genomehelix-turn-helix domain-containing protein3e-1063.9
NC_009783:1956000:195751919575191957785267Vibrio harveyi ATCC BAA-1116 chromosome I, complete sequencehypothetical protein4e-0960.1
NC_007712:1926500:194404719440471944358312Sodalis glossinidius str. 'morsitans', complete genomeputative phage repressor2e-0754.7
NC_012660:3116500:312846731284673128694228Pseudomonas fluorescens SBW25 chromosome, complete genomeputative cro repressor1e-0651.6