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Query: NC_017328:303987:316980 Shigella flexneri 2002017 chromosome, complete genome

Start: 316980, End: 317288, Length: 309

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011601:717072:728867728867729175309Escherichia coli O127:H6 str. E2348/69 chromosome, complete genomeearly gene regulator8e-49192
NC_011751:1405381:141741414174141417806393Escherichia coli UMN026 chromosome, complete genomeputative regulatory protein N1e-48191
NC_011740:2072173:211210021121002112525426Escherichia fergusonii ATCC 35469, complete genomeconserved hypothetical protein from phage origin1e-32138
NC_016860:364981:377118377118377420303Salmonella enterica subsp. enterica serovar Typhimurium strhypothetical protein3e-32137
NC_011147:2496808:251431725143172514619303Salmonella enterica subsp. enterica serovar Paratyphi A strhypothetical protein4e-32136
NC_006511:2501500:251878125187812519083303Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCChypothetical protein4e-32136
NC_006905:368942:382199382199382501303Salmonella enterica subsp. enterica serovar Choleraesuis strantitermination protein2e-25114
NC_011205:609464:625524625524625856333Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853gp545e-2199.8
NC_012125:1330066:134402713440271344365339Salmonella enterica subsp. enterica serovar Paratyphi C strainbacteriophage ST64T protein 246e-2199.4
NC_013282:1200993:121313312131331213474342Cronobacter turicensis, complete genomeProbable regulatory protein N2e-1684.3
NC_009778:2993218:301767730176773018009333Enterobacter sakazakii ATCC BAA-894, complete genomehypothetical protein1e-1582
NC_013361:3287671:329656732965673296839273Escherichia coli O26:H11 str. 11368 chromosome, complete genomeantitermination protein N3e-1373.9
NC_013941:975353:987759987759988103345Escherichia coli O55:H7 str. CB9615 chromosome, complete genomeN protein1e-0652
NC_008563:1175035:118561511856151185959345Escherichia coli APEC O1, complete genomeN protein1e-0652
NC_007946:1239278:124822712482271248571345Escherichia coli UTI89, complete genomeN protein1e-0652
NC_011601:1039500:105013710501371050409273Escherichia coli O127:H6 str. E2348/69 chromosome, complete genomeantitermination protein1e-0652
NC_013364:2645438:265332626533262653598273Escherichia coli O111:H- str. 11128, complete genomeantitermination protein N2e-0650.8