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Query: NC_017328:303987:313857 Shigella flexneri 2002017 chromosome, complete genome

Start: 313857, End: 314024, Length: 168

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009800:289000:295797295797295964168Escherichia coli HS, complete genomehypothetical protein4e-25113
NC_011601:717072:725038725038725205168Escherichia coli O127:H6 str. E2348/69 chromosome, complete genomehypothetical protein4e-24110
NC_013364:2645438:265640126564012656568168Escherichia coli O111:H- str. 11128, complete genomehypothetical protein5e-23106
NC_013361:1558423:156516515651651565329165Escherichia coli O26:H11 str. 11368 chromosome, complete genomehypothetical protein6e-2199.4
NC_011094:593100:605044605044605208165Salmonella enterica subsp. enterica serovar Schwarzengrund strhypothetical protein8e-2199
NC_016860:364981:372417372417372587171Salmonella enterica subsp. enterica serovar Typhimurium strhypothetical protein4e-1580.1
NC_011205:609464:621881621881622051171Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853hypothetical protein2e-1477.8
NC_013282:1200993:120951912095191209674156Cronobacter turicensis, complete genomehypothetical protein3e-0753.5