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Query: NC_017179:805867 Clostridium difficile BI1, complete genome

Start: 805867, End: 839652, Length: 33786

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_013316:79689579689582176924875Clostridium difficile R20291, complete genome020750BLASTN svgBLASTP svg
NC_009089:87329587329590009926805Clostridium difficile 630, complete genome020500BLASTN svgBLASTP svg
NC_014328:40737144073714410040726694Clostridium ljungdahlii ATCC 49587 chromosome, complete genome1e-89339BLASTN svgBLASTP svg
NC_014614:13092031309203133281723615Clostridium sticklandii, complete genome4e-86327BLASTN svgBLASTP svg
NC_008262:2649289*2649289270467655388Clostridium perfringens SM101, complete genome1e-18103BLASTN svgBLASTP svg
NC_014393:4541000*4541000456644025441Clostridium cellulovorans 743B chromosome, complete genome7e-1797.6BLASTN svgBLASTP svg
NC_008593:153014*15301417175318740Clostridium novyi NT, complete genome7e-1487.7BLASTN svgBLASTP svg
NC_010723:173280*17328022135248073Clostridium botulinum E3 str. Alaska E43, complete genome1e-1283.8BLASTN svgBLASTP svg
NC_020291:117983*11798315068032698Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome4e-1281.8BLASTN svgBLASTP svg
NC_015958:2361551*2361551238227520725Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genome4e-1281.8BLASTN svgBLASTP svg
NC_009089:96595996595998833722379Clostridium difficile 630, complete genome2e-1179.8BLASTN svgBLASTP svg
NC_012563:4004709*4004709403727332565Clostridium botulinum A2 str. Kyoto, complete genome2e-1179.8BLASTN svgBLASTP svg
NC_018515:3600869*3600869363009929231Desulfosporosinus meridiei DSM 13257 chromosome, complete genome3e-1075.8BLASTN svgBLASTP svg
NC_015519:58600058600060725221253Tepidanaerobacter sp. Re1 chromosome, complete genome3e-1075.8BLASTN svgBLASTP svg
NC_009089:38898113889811392148531675Clostridium difficile 630, complete genome4e-0971.9BLASTN svgBLASTP svg
NC_010516:3807780*3807780384035532576Clostridium botulinum B1 str. Okra, complete genome4e-0971.9BLASTN svgBLASTP svg
NC_013316:89178289178291434722566Clostridium difficile R20291, complete genome4e-0971.9BLASTN svgBLASTP svg
NC_014150:23999972399997242070520709Brachyspira murdochii DSM 12563 chromosome, complete genome4e-0971.9BLASTN svgBLASTP svg
NC_015687:3326461*3326461335126824808Clostridium acetobutylicum DSM 1731 chromosome, complete genome2e-0869.9BLASTN svgBLASTP svg
NC_003030:3324834*3324834334964224809Clostridium acetobutylicum ATCC 824, complete genome2e-0869.9BLASTN svgBLASTP svg
NC_021182:4602683*4602683462770125019Clostridium pasteurianum BC1, complete genome4e-0661.9BLASTN svgBLASTP svg
NC_008262:90400090400092609922100Clostridium perfringens SM101, complete genome4e-0661.9BLASTN svgBLASTP svg
NC_003366:98110598110599989218788Clostridium perfringens str. 13, complete genome4e-0661.9BLASTN svgBLASTP svg