Pre_GI: BLASTP Hits

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Query: NC_017177:136082:138056 Clostridium difficile BI1, complete genome

Start: 138056, End: 138880, Length: 825

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium difficile BI1 is a human strain isolated in the United States in 1988. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. C. difficile infection represents one of the most common nosocomial (originating in a hospital) infections. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Cytotoxin B depolymerizes actin, the major protein of the cytoskeleton, and thus aids in destruction of tissues. The combined action of the toxins results in necrosis of superficial epithelium and edema (fluidic swelling) in affected areas of intestine. Proliferation of C. difficile is normally prevented by normal intestinal microflora, which is believed to inhibit attachment of the bacterium and its toxins to intestinal walls. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017177:91993:111492111492112439948Clostridium difficile BI1, complete genomehypothetical protein5e-94344
NC_017177:91993:1083451083451093671023Clostridium difficile BI1, complete genomehypothetical protein3e-90331
NC_017177:91993:1047141047141057301017Clostridium difficile BI1, complete genomehypothetical protein2e-76285
NC_017177:91993:121784121784122584801Clostridium difficile BI1, complete genomehypothetical protein2e-69262
NC_017177:136082:139285139285140004720Clostridium difficile BI1, complete genomehypothetical protein1e-59229
NC_017177:175000:1866711866711876751005Clostridium difficile BI1, complete genomehypothetical protein4e-56218
NC_017177:175000:1817061817061832891584Clostridium difficile BI1, complete genomehypothetical protein1e-55216
NC_017177:91993:1021481021481044662319Clostridium difficile BI1, complete genomehypothetical protein2e-55215
NC_017177:136082:140392140392140997606Clostridium difficile BI1, complete genomehypothetical protein3e-55215
NC_017177:175000:1795451795451805911047Clostridium difficile BI1, complete genomehypothetical protein8e-53207
NC_017177:91993:991579915799837681Clostridium difficile BI1, complete genomehypothetical protein8e-51200
NC_017177:91993:100796100796101341546Clostridium difficile BI1, complete genomehypothetical protein3e-49195
NC_017177:136082:1456741456741477492076Clostridium difficile BI1, complete genomehypothetical protein1e-48193
NC_017177:136082:152286152286152945660Clostridium difficile BI1, complete genomehypothetical protein3e-48192
NC_017177:91993:977499774998573825Clostridium difficile BI1, complete genomehypothetical protein2e-43176
NC_013316:891782:9087929087929098021011Clostridium difficile R20291, complete genomehypothetical protein2e-43175
NC_013315:895500:9111779111779121871011Clostridium difficile CD196 chromosome, complete genomehypothetical protein2e-43175
NC_017179:905347:9209549209549219641011Clostridium difficile BI1, complete genomehypothetical protein2e-43175
NC_009089:965959:9815669815669825761011Clostridium difficile 630, complete genomehypothetical protein4e-43174
NC_017177:175000:177542177542178420879Clostridium difficile BI1, complete genomehypothetical protein6e-42171
NC_017177:91993:124467124467124907441Clostridium difficile BI1, complete genomehypothetical protein9e-40164
NC_017177:91993:112814112814113497684Clostridium difficile BI1, complete genomehypothetical protein5e-39161
NC_017177:175000:180704180704181534831Clostridium difficile BI1, complete genomehypothetical protein4e-35148
NC_017177:175000:175873175873176235363Clostridium difficile BI1, complete genomehypothetical protein9e-34144
NC_017177:91993:120684120684121265582Clostridium difficile BI1, complete genomehypothetical protein5e-29128
NC_017177:175000:183584183584184042459Clostridium difficile BI1, complete genomehypothetical protein2e-28126
NC_017177:91993:100130100130100612483Clostridium difficile BI1, complete genomehypothetical protein2e-27122
NC_017177:91993:123205123205123693489Clostridium difficile BI1, complete genomehypothetical protein3e-25115
NC_017177:91993:967139671397126414Clostridium difficile BI1, complete genomehypothetical protein3e-23108
NC_017177:91993:124092124092124439348Clostridium difficile BI1, complete genomehypothetical protein7e-23107
NC_017177:91993:945479454795110564Clostridium difficile BI1, complete genomehypothetical protein1e-21103
NC_015578:2341026:2350601235060123536843084Treponema primitia ZAS-2 chromosome, complete genomehypothetical protein1e-20100
NC_015578:2341026:2366628236662823696092982Treponema primitia ZAS-2 chromosome, complete genomehypothetical protein8e-21100
NC_015578:2341026:2355045235504523581283084Treponema primitia ZAS-2 chromosome, complete genomehypothetical protein9e-1994.4
NC_011830:2177187:220330322033032204103801Desulfitobacterium hafniense DCB-2, complete genomehypothetical protein4e-1582
NC_017177:175000:176240176240176494255Clostridium difficile BI1, complete genomehypothetical protein5e-1478.2
NC_017177:175000:178802178802179362561Clostridium difficile BI1, complete genomehypothetical protein6e-1478.2
NC_012969:2136243:218866821886682189555888Methylovorus glucosetrophus SIP3-4 chromosome, complete genomehypothetical protein2e-1376.3
NC_017177:136082:143244143244143444201Clostridium difficile BI1, complete genomehypothetical protein7e-1374.3
NC_014638:363577:3806973806973835072811Bifidobacterium bifidum PRL2010 chromosome, complete genomehypothetical protein4e-1272
NC_017177:175000:178581178581178799219Clostridium difficile BI1, complete genomehypothetical protein2e-1066.6
NC_008529:906576:9750949750949778202727Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365, completehypothetical protein7e-0857.8
NC_015761:1970042:1980567198056719824561890Salmonella bongori NCTC 12419, complete genomevirulence protein1e-0757