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Query: NC_016911:278415:293841 Rickettsia rickettsii str. Hauke chromosome, complete genome

Start: 293841, End: 293975, Length: 135

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012633:276500:291728291728292120393Rickettsia africae ESF-5, complete genomehypothetical protein3e-1477
NC_015866:274550:2941982941982954211224Rickettsia heilongjiangensis 054 chromosome, complete genomehypothetical protein4e-1270.1
NC_016931:269537:286610286610286846237Rickettsia massiliae str. AZT80 chromosome, complete genomehypothetical protein3e-1063.9
NC_017043:990395:101044110104411011076636Rickettsia montanensis str. OSU 85-930 chromosome, complete genomehypothetical protein3e-1063.5
NC_009882:278384:293809293809293943135Rickettsia rickettsii str. 'Sheila Smith', complete genomehypothetical protein9e-1889
NC_016909:278327:293753293753293887135Rickettsia rickettsii str. Arizona chromosome, complete genomehypothetical protein4e-1890.1
NC_016913:859931:875083875083875217135Rickettsia rickettsii str. Brazil chromosome, complete genomehypothetical protein4e-1890.1
NC_016908:278457:293880293880294014135Rickettsia rickettsii str. Colombia chromosome, complete genomehypothetical protein4e-1890.1
NC_016914:278500:293974293974294108135Rickettsia rickettsii str. Hino chromosome, complete genomehypothetical protein4e-1890.1
NC_010263:278463:293888293888294022135Rickettsia rickettsii str. Iowa, complete genomehypothetical protein4e-1890.1