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Query: NC_016822:1339058:1349975 Shigella sonnei 53G, complete genome

Start: 1349975, End: 1350187, Length: 213

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011741:1978500:199712019971201997974855Escherichia coli IAI1 chromosome, complete genomehypothetical protein5e-35145
CU928160:1978500:199712019971201997974855Escherichia coli IAI1 chromosome, complete genomeconserved hypothetical protein; CymJ protein, transcriptional regulator domain5e-35145
NC_013364:2355298:237393223739322374741810Escherichia coli O111:H- str. 11128, complete genomeputative transcriptional regulator6e-35145
NC_013361:2591829:261046326104632611272810Escherichia coli O26:H11 str. 11368 chromosome, complete genometranscriptional regulator6e-35145
NC_007384:1355060:136712713671271367366240Shigella sonnei Ss046, complete genomehypothetical protein7e-35145
NC_015637:891842:907647907647908471825Vibrio anguillarum 775 chromosome chromosome II, complete sequencetranscriptional regulator5e-1682.8