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Query: NC_016768:830000:851943 Mycobacterium tuberculosis KZN 4207 chromosome, complete genome

Start: 851943, End: 852668, Length: 726

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012943:830000:851939851939852664726Mycobacterium tuberculosis KZN 1435 chromosome, complete genomehypothetical protein4e-115414
NC_002945:831029:852931852931853656726Mycobacterium bovis AF2122/97, complete genomehypothetical protein4e-115414
NC_012207:831030:852884852884853609726Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein4e-115414
NC_008595:661507:675903675903676619717Mycobacterium avium 104, complete genomehypothetical protein1e-83309
NC_010612:103081:1294871294871305781092Mycobacterium marinum M, complete genomehypothetical protein8e-48190
NC_020133:77341:908559085591619765Mycobacterium liflandii 128FXT, complete genomehypothetical protein1e-47189
NC_018581:3871000:388555238855523886520969Gordonia sp. KTR9 chromosome, complete genomehypothetical protein3e-23108