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Query: NC_016768:830000:842430 Mycobacterium tuberculosis KZN 4207 chromosome, complete genome

Start: 842430, End: 842858, Length: 429

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:829444:841724841724842152429Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein2e-69260
NC_002945:831029:843418843418843846429Mycobacterium bovis AF2122/97, complete genomehypothetical protein2e-69260
NC_002755:831397:843369843369843797429Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein2e-69260
NC_009565:833076:845097845097845525429Mycobacterium tuberculosis F11, complete genomehypothetical protein2e-69260
NC_009525:830513:842534842534842962429Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein2e-69260
NC_012943:830000:842426842426842854429Mycobacterium tuberculosis KZN 1435 chromosome, complete genometoxin2e-69260
NC_016804:831500:843290843290843718429Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein7e-69258
NC_012207:831030:843371843371843799429Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein7e-69258
NC_008769:860670:873011873011873439429Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein7e-69258
NC_009338:955195:973707973707974144438Mycobacterium gilvum PYR-GCK chromosome, complete genomePilT domain-containing protein1e-1272