Pre_GI: BLASTP Hits

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Query: NC_016768:830000:834890 Mycobacterium tuberculosis KZN 4207 chromosome, complete genome

Start: 834890, End: 835447, Length: 558

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:829444:834383834383834940558Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein6e-97352
NC_009565:833076:837755837755838312558Mycobacterium tuberculosis F11, complete genomehypothetical protein6e-97352
NC_012207:831030:835711835711836268558Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein6e-97352
NC_008769:860670:865351865351865908558Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein6e-97352
NC_009525:830513:835192835192835749558Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein6e-97352
NC_002755:831397:836075836075836632558Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein6e-97352
NC_002945:831029:835710835710836267558Mycobacterium bovis AF2122/97, complete genomehypothetical protein6e-97352
NC_012943:830000:834886834886835443558Mycobacterium tuberculosis KZN 1435 chromosome, complete genomehypothetical protein6e-97352
NC_016804:831500:835630835630836187558Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein6e-97352
NC_014151:856354:861027861027861578552Cellulomonas flavigena DSM 20109 chromosome, complete genomehypothetical protein6e-35147
NC_008699:3516608:353827335382733538836564Nocardioides sp. JS614, complete genomehypothetical protein2e-26118
NC_015588:1213873:121992412199241220490567Isoptericola variabilis 225 chromosome, complete genomehypothetical protein4e-26117
NC_008726:3858209:386557538655753866156582Mycobacterium vanbaalenii PYR-1, complete genomeconserved hypothetical protein1e-23108
NC_017904:2353800:236313823631382363716579Mycobacterium sp. MOTT36Y chromosome, complete genomehypothetical protein1e-22106
NC_015422:910292:920077920077920622546Alicycliphilus denitrificans K601 chromosome, complete genomehypothetical protein5e-1787.4
NC_008758:143907:166252166252166830579Polaromonas naphthalenivorans CJ2 plasmid pPNAP02, completehypothetical protein5e-1167.4
NC_015376:903939:918475918475919254780Burkholderia gladioli BSR3 chromosome chromosome 2, completehypothetical protein2e-0858.9