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Query: NC_016768:830000:830211 Mycobacterium tuberculosis KZN 4207 chromosome, complete genome

Start: 830211, End: 830708, Length: 498

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:829444:829704829704830201498Mycobacterium tuberculosis RGTB327 chromosome, complete genomeMarR family transcriptional regulator6e-79292
NC_008769:860670:860670860670861167498Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative transcriptional regulatory protein6e-79292
NC_012207:831030:831030831030831527498Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative transcriptional regulatory protein6e-79292
NC_002945:831029:831029831029831526498Mycobacterium bovis AF2122/97, complete genometranscriptional regulatory protein6e-79292
NC_009565:833076:833076833076833573498Mycobacterium tuberculosis F11, complete genomehypothetical transcriptional regulatory protein6e-79292
NC_002755:831397:831397831397831894498Mycobacterium tuberculosis CDC1551, complete genometranscriptional regulator, MarR family6e-79292
NC_009525:830513:830513830513831010498Mycobacterium tuberculosis H37Ra, complete genomeputative transcriptional regulatory protein6e-79292
NC_012943:830000:830207830207830704498Mycobacterium tuberculosis KZN 1435 chromosome, complete genometranscriptional regulator6e-79292
NC_019673:8057941:806683980668398067342504Saccharothrix espanaensis DSM 44229 complete genomeTranscriptional regulator, MarR family6e-24109
NC_013595:4796436:482363748236374824152516Streptosporangium roseum DSM 43021, complete genomehypothetical protein2e-0652