Pre_GI: BLASTP Hits

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Query: NC_016768:2101751:2102283 Mycobacterium tuberculosis KZN 4207 chromosome, complete genome

Start: 2102283, End: 2103887, Length: 1605

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016804:2254979:2273930227393022755341605Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein0882
NC_012943:2103662:2104194210419421057981605Mycobacterium tuberculosis KZN 1435 chromosome, complete genomehypothetical protein0882
NC_009565:2306574:2325525232552523271291605Mycobacterium tuberculosis F11, complete genomehypothetical protein0882
NC_017186:5184000:5202878520287852044731596Amycolatopsis mediterranei S699 chromosome, complete genomeamidohydrolase4e-122439
NC_014318:5183975:5202844520284452044391596Amycolatopsis mediterranei U32 chromosome, complete genomeamidohydrolase4e-122439
NC_007777:2638580:2650987265098726526331647Frankia sp. CcI3, complete genomeAmidohydrolase 38e-84311
NC_008278:4023918:4041168404116840427691602Frankia alni ACN14a, complete genomeconserved hypothetical protein; putative metallo-dependent hydrolase domain2e-82306
NC_009953:2727669:2738129273812927396941566Salinispora arenicola CNS-205 chromosome, complete genomeamidohydrolase 35e-74278
NC_013174:1366786:1382767138276713843921626Jonesia denitrificans DSM 20603, complete genomeAmidohydrolase 31e-71270
NC_009921:4948500:4960385496038549620761692Frankia sp. EAN1pec, complete genomeAmidohydrolase 36e-68258
NC_015434:3507059:3515997351599735174301434Verrucosispora maris AB-18-032 chromosome, complete genomeamidohydrolase 31e-66254
NC_009380:2548878:2558288255828825597841497Salinispora tropica CNB-440 chromosome, complete genomeamidohydrolase 32e-65250
NC_011831:1610346:1631230163123016328281599Chloroflexus aggregans DSM 9485, complete genomeAmidohydrolase 38e-1479
NC_011769:787496:7874967874967891181623Desulfovibrio vulgaris str. 'Miyazaki F', complete genomeAmidohydrolase 32e-1378.2
NC_014924:2399524:2424848242484824265721725Pseudoxanthomonas suwonensis 11-1 chromosome, complete genomeAmidohydrolase 33e-1377
NC_010338:4481356:4481356448135644829901635Caulobacter sp. K31, complete genomeAmidohydrolase 31e-1275.1
NC_009092:1047500:1057371105737110591191749Shewanella loihica PV-4, complete genomeAmidohydrolase 34e-1273.2
NC_011772:4565418:4569412456941245709801569Bacillus cereus G9842, complete genomehypothetical protein5e-1273.2
NC_020291:5778999:5783451578345157852021752Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeputative TIM-barrel fold metal-dependent hydrolase7e-1272.8
NC_013524:171524:1822641822641839761713Sphaerobacter thermophilus DSM 20745 chromosome 2, complete genomeAmidohydrolase 38e-1169.3
NC_011725:4600000:4604131460413146056991569Bacillus cereus B4264 chromosome, complete genomehypothetical protein9e-1168.9
NC_015723:2550000:2570566257056625722421677Cupriavidus necator N-1 chromosome 2, complete sequenceamidohydrolase1e-1068.6
NC_014220:1269870:1285273128527312863791107Syntrophothermus lipocalidus DSM 12680 chromosome, complete genomeAmidohydrolase 33e-1067.4
NC_012522:3867167:3889481388948138911871707Rhodococcus opacus B4, complete genomeputative hydrolase7e-1065.9
UCMB5137:2418403:2423962242396224257941833Bacillus atrophaeus UCMB-5137metal-dependent hydrolase8e-1065.9
NC_016109:6816000:6837766683776668394061641Kitasatospora setae KM-6054, complete genomeputative peptidase M38 family protein1e-0965.5
NC_014639:2452286:2458654245865424604861833Bacillus atrophaeus 1942 chromosome, complete genomemetal-dependent hydrolase2e-0964.7
CP002207:2452286:2458654245865424604861833Bacillus atrophaeus 1942, complete genomemetal-dependent hydrolase2e-0964.7
NC_015510:1978539:1999705199970520012611557Haliscomenobacter hydrossis DSM 1100 chromosome, complete genomeAmidohydrolase 32e-0964.7
NC_007974:1135863:1137708113770811393901683Ralstonia metallidurans CH34 chromosome 2, complete sequenceAmidohydrolase 32e-0964.7
NC_015723:280368:2988722988723008181947Cupriavidus necator N-1 chromosome 2, complete sequenceamidohydrolase1e-0862
NC_015161:792955:7929557929557944691515Deinococcus proteolyticus MRP chromosome, complete genomeAmidohydrolase 34e-0860.1
NC_009922:944538:9445389445389461421605Alkaliphilus oremlandii OhILAs, complete genomeAmidohydrolase 34e-0860.1
NC_009050:604950:6093846093846110361653Rhodobacter sphaeroides ATCC 17029 chromosome 2, complete sequenceAmidohydrolase 35e-0859.7
NC_019908:436000:4421614421614437471587Brachyspira pilosicoli P43/6/78 chromosome, complete genomeamidohydrolase 35e-0859.7
NC_011001:2085986:2146425214642521480501626Burkholderia cenocepacia J2315 chromosome 2, complete sequenceputative amidohydrolase8e-0859.3
NC_012225:212727:2145972145972161441548Brachyspira hyodysenteriae WA1, complete genomeamidohydrolase 39e-0858.9
NC_007333:2093167:2093167209316720947861620Thermobifida fusca YX, complete genomehypothetical protein1e-0758.5
NC_007494:27084:3151831518331701653Rhodobacter sphaeroides 2.4.1 chromosome 2, complete sequencePutative metal-dependent hydrolase2e-0758.2
NC_015977:2631789:2654238265423826558031566Roseburia hominis A2-183 chromosome, complete genomeamidohydrolase1e-0758.2
NC_010184:3213347:3215590321559032172091620Bacillus weihenstephanensis KBAB4, complete genomeAmidohydrolase 32e-0757.8
NC_015566:3269469:3289042328904232909191878Serratia sp. AS12 chromosome, complete genomeAmidohydrolase 33e-0757.4
NC_021184:2936244:2969732296973229714321701Desulfotomaculum gibsoniae DSM 7213, complete genomeputative TIM-barrel fold metal-dependent hydrolase5e-0756.2
NC_013093:1213908:1218379121837912199561578Actinosynnema mirum DSM 43827, complete genomeAmidohydrolase 36e-0756.2
NC_011958:53426:5637756377580291653Rhodobacter sphaeroides KD131 chromosome 2, complete genomeAmidohydrolase 31e-0655.5
NC_008942:1706191:1726815172681517284161602Methanocorpusculum labreanum Z, complete genomehypothetical protein1e-0655.5
NC_014624:1349950:1354311135431113560351725Eubacterium limosum KIST612 chromosome, complete genomeexoenzyme regulatory protein2e-0654.3
NC_014931:1044313:1066641106664110686231983Variovorax paradoxus EPS chromosome, complete genomeAmidohydrolase 33e-0653.9
NC_008044:857759:8780168780168796831668Silicibacter sp. TM1040, complete genomeAmidohydrolase 34e-0653.5
NC_014973:3290545:3316892331689233187031812Geobacter sp. M18 chromosome, complete genomeAmidohydrolase 36e-0652.8