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Query: NC_016768:1769332:1790675 Mycobacterium tuberculosis KZN 4207 chromosome, complete genome

Start: 1790675, End: 1792657, Length: 1983

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016804:2560000:2580283258028325822651983Mycobacterium bovis BCG str. Mexico chromosome, complete genomeputative transmembrane protein0937
NC_012943:1769445:1790788179078817927701983Mycobacterium tuberculosis KZN 1435 chromosome, complete genomehypothetical protein0937
NC_012207:2573562:2593690259369025956721983Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative transmembrane protein0937
NC_016887:1680338:1702193170219317041721980Nocardia cyriacigeorgica GUH-2, complete genomehypothetical protein7e-65249
NC_016948:2033311:205868720586872059571885Mycobacterium intracellulare MOTT-64 chromosome, complete genomehypothetical protein7e-35149
NC_013235:5849659:5851644585164458537312088Nakamurella multipartita DSM 44233, complete genomeprotein of unknown function DUF4772e-26120