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Query: NC_016768:1769332:1769332 Mycobacterium tuberculosis KZN 4207 chromosome, complete genome

Start: 1769332, End: 1770129, Length: 798

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012943:1769445:176944517694451770242798Mycobacterium tuberculosis KZN 1435 chromosome, complete genomeDNA repair protein RecO6e-142503
NC_009525:2635792:265542926554292656226798Mycobacterium tuberculosis H37Ra, complete genomeDNA repair protein RecO6e-142503
NC_015848:2684275:270207427020742702871798Mycobacterium canettii CIPT 140010059, complete genomehypothetical protein6e-142503
NC_010612:4501414:451969145196914520488798Mycobacterium marinum M, complete genomerecombination protein O RecO6e-132469
NC_016887:1680338:169356116935611694340780Nocardia cyriacigeorgica GUH-2, complete genomeDNA repair protein recO (Recombination protein O)6e-96350
NC_006087:1483761:149999114999911500740750Leifsonia xyli subsp. xyli str. CTCB07, complete genomeDNA repair protein RecO1e-57223
NC_015957:8845274:885938088593808860138759Streptomyces violaceusniger Tu 4113 chromosome, complete genomeDNA repair protein recO5e-57221
NC_010617:1428902:144945414494541450212759Kocuria rhizophila DC2201, complete genomeDNA repair protein RecO4e-55214
NC_014643:2056280:213785821378582138625768Rothia dentocariosa ATCC 17931 chromosome, complete genomerecombination protein O1e-30133
NC_009633:3055413:305776730577673058507741Alkaliphilus metalliredigens QYMF chromosome, complete genomeDNA repair protein RecO4e-1582
NC_006322:2592176:261616126161612616931771Bacillus licheniformis ATCC 14580, complete genomeDNA repair protein RecO4e-1478.6
NC_011146:3206000:322908932290893229742654Geobacter bemidjiensis Bem, complete genomeDNA repair protein RecO5e-1478.2
NC_014623:6150028:618223861822386182972735Stigmatella aurantiaca DW4/3-1 chromosome, complete genomeDNA repair protein RecO1e-1170.5
NC_012483:656397:675950675950676705756Acidobacterium capsulatum ATCC 51196, complete genomeDNA repair protein RecO4e-0962
NC_014972:3000138:300724430072443008014771Desulfobulbus propionicus DSM 2032 chromosome, complete genomeDNA repair protein RecO6e-0961.6
NC_002939:579087:606305606305607036732Geobacter sulfurreducens PCA, complete genomeDNA repair protein RecO7e-0961.2