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Query: NC_016768:1279178:1285508 Mycobacterium tuberculosis KZN 4207 chromosome, complete genome

Start: 1285508, End: 1286416, Length: 909

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:3110155:312120731212073122115909Mycobacterium tuberculosis RGTB327 chromosome, complete genomecsm4 family CRISPR-associated ramp protein2e-173607
NC_002755:3110929:312156931215693122477909Mycobacterium tuberculosis CDC1551, complete genomeCRISPR-associated TM1808 family protein2e-173607
NC_012207:3063039:307411430741143075022909Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein2e-173607
NC_009565:3128094:313899331389933139901909Mycobacterium tuberculosis F11, complete genomehypothetical protein2e-173607
NC_009525:3128786:313935531393553140263909Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein2e-173607
NC_008769:3070266:308134130813413082249909Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein2e-173607
NC_002945:3073370:308392630839263084834909Mycobacterium bovis AF2122/97, complete genomehypothetical protein2e-173607
NC_000962:3116818:312736431273643128272909Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein2e-173607
NC_012943:1279228:128556412855641286472909Mycobacterium tuberculosis KZN 1435 chromosome, complete genomecsm4 family CRISPR-associated ramp protein2e-173607
NC_016804:3049631:306070630607063061614909Mycobacterium bovis BCG str. Mexico chromosome, complete genomeCsm4 family CRISPR-associated ramp protein2e-173607
NC_019950:3139865:315173431517343152642909Mycobacterium canettii CIPT 140060008 complete genomeConserved CRISPR-associated protein of unknown function Csm41e-152538
NC_015848:3175692:318735131873513188259909Mycobacterium canettii CIPT 140010059, complete genomehypothetical protein1e-152538
NC_015873:1487127:1498554149855414995641011Megasphaera elsdenii DSM 20460, complete genomeCRISPR-associated RAMP protein2e-20100
NC_013501:1881692:189481018948101895802993Rhodothermus marinus DSM 4252, complete genomeCRISPR-associated RAMP protein, Csm4 family3e-1169.7
NC_009718:1470972:150144215014421502407966Fervidobacterium nodosum Rt17-B1, complete genomeCRISPR-associated RAMP Csm4 family protein6e-1065.1
NC_008639:2358592:2369102236910223701661065Chlorobium phaeobacteroides DSM 266, complete genomeCRISPR-associated RAMP protein, Csm4 family3e-0859.3
NC_014377:532816:537033537033537992960Thermosediminibacter oceani DSM 16646 chromosome, complete genomeCRISPR-associated RAMP protein, Csm4 family5e-0858.5