Pre_GI: BLASTP Hits

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Query: NC_016768:1279178:1284817 Mycobacterium tuberculosis KZN 4207 chromosome, complete genome

Start: 1284817, End: 1285527, Length: 711

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013926:974668:986479986479987297819Aciduliprofundum boonei T469 chromosome, complete genomeCRISPR-associated RAMP protein, Csm3 family4e-1994.7
NC_008639:2358592:237017723701772371034858Chlorobium phaeobacteroides DSM 266, complete genomeCRISPR-associated RAMP protein, Csm3 family1e-24113
NC_015388:1913118:192196319219631922811849Desulfobacca acetoxidans DSM 11109 chromosome, complete genomeCRISPR-associated RAMP protein, Csm3 family1e-1893.6
NC_015565:624298:627283627283627936654Desulfotomaculum carboxydivorans CO-1-SRB chromosome, completeCRISPR-associated RAMP protein, Csm3 family3e-24111
NC_014836:1108919:111814911181491118886738Desulfurispirillum indicum S5 chromosome, complete genomeCsm3 family CRISPR-associated RAMP protein4e-1891.7
NC_009718:1470972:150066315006631501391729Fervidobacterium nodosum Rt17-B1, complete genomeCRISPR-associated RAMP Csm3 family protein2e-23109
NC_006300:1624254:164164416416441642339696Mannheimia succiniciproducens MBEL55E, complete genomehypothetical protein3e-28125
NC_015873:1487127:149786714978671498550684Megasphaera elsdenii DSM 20460, complete genomeCRISPR-associated RAMP protein1e-35149
NC_014212:670996:691237691237691914678Meiothermus silvanus DSM 9946 chromosome, complete genomeCRISPR-associated RAMP protein, Csm3 family5e-27120
NC_013407:1205747:120989712098971210778882Methanocaldococcus vulcanius M7, complete genomeCRISPR-associated RAMP protein, Csm3 family9e-31133
NC_000916:983500:995646995646996383738Methanothermobacter thermautotrophicus str. Delta H, completehypothetical protein3e-26118
NC_015562:1230532:1253761125376112547891029Methanotorris igneus Kol 5 chromosome, complete genomeCRISPR-associated RAMP protein, Csm3 family7e-1064.3
NC_002945:3073370:308481530848153085525711Mycobacterium bovis AF2122/97, complete genomehypothetical protein3e-134477
NC_016804:3049631:306159530615953062305711Mycobacterium bovis BCG str. Mexico chromosome, complete genomeCsm3 family CRISPR-associated ramp protein3e-134477
NC_008769:3070266:308223030822303082940711Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein3e-134477
NC_012207:3063039:307500330750033075713711Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein3e-134477
NC_015848:3175692:318824031882403188950711Mycobacterium canettii CIPT 140010059, complete genomehypothetical protein4e-122437
NC_019950:3139865:315262331526233153333711Mycobacterium canettii CIPT 140060008 complete genomeConserved CRISPR-associated protein of unknown function Csm34e-122437
NC_002755:3110929:312245831224583123168711Mycobacterium tuberculosis CDC1551, complete genomeCRISPR-associated TM1792 family protein3e-134477
NC_009565:3128094:313988231398823140592711Mycobacterium tuberculosis F11, complete genomehypothetical protein3e-134477
NC_009525:3128786:314024431402443140954711Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein3e-134477
NC_000962:3116818:312825331282533128963711Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein3e-134477
NC_012943:1279228:128487312848731285583711Mycobacterium tuberculosis KZN 1435 chromosome, complete genomecsm3 family CRISPR-associated ramp protein3e-134477
NC_017026:3110155:312209631220963122806711Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein3e-134477
NC_011060:2525367:253634325363432537200858Pelodictyon phaeoclathratiforme BU-1, complete genomeCRISPR-associated RAMP protein, Csm3 family9e-26117
NC_000961:135493:142867142867143742876Pyrococcus horikoshii OT3, complete genomehypothetical protein4e-27121
NC_013501:1881692:189579918957991896593795Rhodothermus marinus DSM 4252, complete genomeCRISPR-associated RAMP protein, Csm3 family6e-24110
NC_016940:190986:202945202945203691747Saprospira grandis str. Lewin chromosome, complete genomeCRISPR-associated RAMP Csm3 family protein5e-24111
NC_008554:1664131:167147716714771672202726Syntrophobacter fumaroxidans MPOB, complete genomeCRISPR-associated RAMP protein, Csm3 family6e-22104
NC_016610:2489415:250240925024092503047639Tannerella forsythia ATCC 43037 chromosome, complete genomeCsm3 family CRISPR-associated RAMP protein1e-27123
NC_011529:806000:823745823745824617873Thermococcus onnurineus NA1, complete genomehypothetical protein3e-29128
NC_002689:78297:114661114661115350690Thermoplasma volcanium GSS1, complete genomehypothetical protein5e-1994.7
NC_010525:1041493:104058210405821041505924Thermoproteus neutrophilus V24Sta, complete genomeCRISPR-associated RAMP protein, Csm3 family5e-1374.7
NC_014377:532816:536208536208537026819Thermosediminibacter oceani DSM 16646 chromosome, complete genomeCRISPR-associated protein, Csm3 family1e-2099.8
NC_009486:1103915:112344911234491124192744Thermotoga petrophila RKU-1 chromosome, complete genomeCRISPR-associated RAMP Csm3 family protein3e-30131
NC_014926:819163:828561828561829271711Thermovibrio ammonificans HB-1 chromosome, complete genomeCRISPR-associated RAMP protein, Csm3 family2e-1892.8
NC_015151:1427965:147697814769781477955978Vulcanisaeta moutnovskia 768-28 chromosome, complete genomeCRISPR-associated RAMP protein, Csm3 family3e-0858.9