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Query: NC_016768:1279178:1284433 Mycobacterium tuberculosis KZN 4207 chromosome, complete genome

Start: 1284433, End: 1284807, Length: 375

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:3110155:312281631228163123190375Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein8e-67251
NC_008769:3070266:308295030829503083324375Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein8e-67251
NC_012207:3063039:307572330757233076097375Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein8e-67251
NC_009565:3128094:314060231406023140976375Mycobacterium tuberculosis F11, complete genomehypothetical protein8e-67251
NC_002945:3073370:308553530855353085909375Mycobacterium bovis AF2122/97, complete genomehypothetical protein8e-67251
NC_000962:3116818:312897331289733129347375Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein8e-67251
NC_009525:3128786:314096431409643141338375Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein8e-67251
NC_002755:3110929:312317831231783123552375Mycobacterium tuberculosis CDC1551, complete genomeCRISPR-associated TM1810 family protein8e-67251
NC_012943:1279228:128448912844891284863375Mycobacterium tuberculosis KZN 1435 chromosome, complete genomehypothetical protein8e-67251
NC_016804:3049631:306231530623153062689375Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein8e-67251
NC_015848:3175692:318894731889473189339393Mycobacterium canettii CIPT 140010059, complete genomehypothetical protein1e-45181
NC_019950:3139865:315333031533303153722393Mycobacterium canettii CIPT 140060008 complete genomeConserved CRISPR-associated protein of unknown function Csm21e-45181
NC_015873:1487127:149748414974841497864381Megasphaera elsdenii DSM 20460, complete genomeCRISPR-associated protein2e-1167.8