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Query: NC_016768:1279178:1281057 Mycobacterium tuberculosis KZN 4207 chromosome, complete genome

Start: 1281057, End: 1282001, Length: 945

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:3110155:312561331256133126557945Mycobacterium tuberculosis RGTB327 chromosome, complete genomeCRISPR-associated protein Cas60636
NC_009565:3128094:314340831434083144352945Mycobacterium tuberculosis F11, complete genomehypothetical protein0636
NC_009525:3128786:314376131437613144705945Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein0636
NC_008769:3070266:308575630857563086700945Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein0636
NC_000962:3116818:313177031317703132714945Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein0636
NC_002755:3110929:312598431259843126928945Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein0636
NC_012207:3063039:307852930785293079473945Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein0636
NC_012943:1279228:128111312811131282057945Mycobacterium tuberculosis KZN 1435 chromosome, complete genomehypothetical protein0636
NC_016804:3049631:306512130651213066065945Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein0636
NC_002945:3073370:308834130883413089285945Mycobacterium bovis AF2122/97, complete genomehypothetical protein1e-180632
NC_019950:3139865:315615731561573156945789Mycobacterium canettii CIPT 140060008 complete genomeConserved CRISPR-associated protein of unknown function Cas64e-143507
NC_015873:1487127:150073615007361501485750Megasphaera elsdenii DSM 20460, complete genomehypothetical protein8e-2097.8
NC_014926:819163:825555825555826382828Thermovibrio ammonificans HB-1 chromosome, complete genomeCRISPR-associated protein Cas61e-0654.3