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Query: NC_012943:2707677:2734294 Mycobacterium tuberculosis KZN 1435 chromosome, complete genome

Start: 2734294, End: 2734524, Length: 231

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: M. tuberculosis strain KZN 1435 was isolated from a patient in KwaZulu-Natal, South Africa. This strain is multidrug-resistant (resistant to isoniazid and rifampin). This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. This species is responsible for more morbidity in humans than any other bacterial disease. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. The envelope contains the typical polypeptide layer, the peptidoglycan layer, and free lipids. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. These fatty acid-carbohydrate complexes inhibit phago-lysosome fusion and are often considered to be indicators of virulent strains. The cell envelope also includes adhesins and aggressions, but does not contain any known toxins. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_002944:1285436:1285436128543612876882253Mycobacterium avium subsp. paratuberculosis K-10, complete genomemethylmalonyl-CoA mutase8e-1062.4
NC_002945:1680751:1680751168075116830032253Mycobacterium bovis AF2122/97, complete genomemethylmalonyl-CoA mutase6e-0856.2
NC_016804:1679357:1679357167935716816092253Mycobacterium bovis BCG str. Mexico chromosome, complete genomemethylmalonyl-CoA mutase6e-0856.2
NC_008769:1709078:1709078170907817113302253Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative methylmalonyl-COA mutase large subunit mutB6e-0856.2
NC_012207:1681971:1681971168197116842232253Mycobacterium bovis BCG str. Tokyo 172, complete genomemethylmalonyl-COA mutase6e-0856.2
NC_015848:1708176:1708176170817617104282253Mycobacterium canettii CIPT 140010059, complete genomeputative methylmalonyl-CoA mutase large subunit MUTB6e-0856.2
NC_002755:1684161:1684161168416116864132253Mycobacterium tuberculosis CDC1551, complete genomemethylmalonyl-CoA mutase6e-0856.2
NC_009565:1688642:1688642168864216908942253Mycobacterium tuberculosis F11, complete genomemethylmalonyl-CoA mutase large subunit mutB6e-0856.2
NC_009525:1685522:1685522168552216877742253Mycobacterium tuberculosis H37Ra, complete genomeputative methylmalonyl-COA mutase large subunit MutB6e-0856.2
NC_000962:1684005:1684005168400516862572253Mycobacterium tuberculosis H37Rv, complete genomemethylmalonyl-CoA mutase6e-0856.2
NC_012943:2707677:2727209272720927294612253Mycobacterium tuberculosis KZN 1435 chromosome, complete genomemethylmalonyl-CoA mutase6e-0856.2
NC_016768:2704350:2723882272388227261342253Mycobacterium tuberculosis KZN 4207 chromosome, complete genomemethylmalonyl-CoA mutase large subunit mutB6e-0856.2