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Query: NC_012581:1505276:1505276 Bacillus anthracis str. CDC 684 chromosome, complete genome

Start: 1505276, End: 1505713, Length: 438

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_007530:2716885:273297627329762733413438Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein1e-78291
NC_012659:2715651:273287627328762733313438Bacillus anthracis str. A0248, complete genomehypothetical protein1e-78291
NC_003997:2715623:273284827328482733285438Bacillus anthracis str. Ames, complete genomehypothetical protein1e-78291
NC_005945:2716000:273331127333112733748438Bacillus anthracis str. Sterne, complete genomehypothetical protein1e-78291
NC_011773:2782465:279866327986632799100438Bacillus cereus AH820 chromosome, complete genomehypothetical protein1e-78291
NC_003909:2798622:281461628146162815053438Bacillus cereus ATCC 10987, complete genomehypothetical protein1e-76284
NC_014335:2718000:273557427355742736011438Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein2e-78290
NC_006274:2779380:279690027969002797337438Bacillus cereus E33L, complete genomehypothetical protein1e-78291
NC_016779:2693790:271002327100232710460438Bacillus cereus F837/76 chromosome, complete genomehypothetical protein1e-78291
NC_011772:2860000:287825728782572878694438Bacillus cereus G9842, complete genomehypothetical protein8e-76281
NC_011969:2706000:272336027233602723779420Bacillus cereus Q1 chromosome, complete genomehypothetical protein5e-73272
NC_015634:526889:529837529837530244408Bacillus coagulans 2-6 chromosome, complete genomehypothetical protein5e-0753.1
NC_016023:729843:743993743993744400408Bacillus coagulans 36D1 chromosome, complete genomehypothetical protein4e-0753.5
NC_017208:2942554:296065229606522960954303Bacillus thuringiensis serovar chinensis CT-43 chromosome, completeintegral membrane protein3e-50196
NC_005957:2756000:277235227723522772789438Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein1e-78291