Pre_GI: BLASTN Hits

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Query: NC_010723:3434000 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 3434000, End: 3456949, Length: 22950

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_016012:16134*161347078354650Candidatus Arthromitus sp. SFB-rat-Yit, complete genome2e-1075.8BLASTN svgBLASTP svg
NC_010674:21857042185704221026824565Clostridium botulinum B str. Eklund 17B, complete genome3e-0661.9BLASTN svgBLASTP svg
NC_010674:33620713362071338633124261Clostridium botulinum B str. Eklund 17B, complete genome5e-1797.6BLASTN svgBLASTP svg
NC_010674:36197223619722364030220581Clostridium botulinum B str. Eklund 17B, complete genome05475BLASTN svgBLASTP svg
NC_010516:2877407*2877407289845321047Clostridium botulinum B1 str. Okra, complete genome2e-25125BLASTN svgBLASTP svg
NC_014393:1590893*1590893163877247880Clostridium cellulovorans 743B chromosome, complete genome5e-26127BLASTN svgBLASTP svg
NC_008593:980731980731100500724277Clostridium novyi NT, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_008261:576923*57692359692520003Clostridium perfringens ATCC 13124, complete genome2e-75291BLASTN svgBLASTP svg
NC_008261:64678*6467810124836571Clostridium perfringens ATCC 13124, complete genome1e-32149BLASTN svgBLASTP svg
NC_008261:551513*55151357420222690Clostridium perfringens ATCC 13124, complete genome0722BLASTN svgBLASTP svg
NC_008262:67711*677119109923389Clostridium perfringens SM101, complete genome1e-32149BLASTN svgBLASTP svg
NC_003366:64908*6490811367548768Clostridium perfringens str. 13, complete genome1e-32149BLASTN svgBLASTP svg
NC_003366:61379861379863609922302Clostridium perfringens str. 13, complete genome5e-85323BLASTN svgBLASTP svg
NC_020291:59810065981006600872727722Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome7e-1073.8BLASTN svgBLASTP svg
NC_020134:34340234340236367520274Clostridium stercorarium subsp. stercorarium DSM 8532, complete2e-0765.9BLASTN svgBLASTP svg
NC_015565:27365002736500277293936440Desulfotomaculum carboxydivorans CO-1-SRB chromosome, complete4e-0867.9BLASTN svgBLASTP svg
NC_019978:23640002364000238561421615Halobacteroides halobius DSM 5150, complete genome1e-1179.8BLASTN svgBLASTP svg
NC_015958:81544281544283814622705Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genome9e-31143BLASTN svgBLASTP svg