Pre_GI: BLASTP Hits

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Query: NC_010723:622928:623802 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 623802, End: 624725, Length: 924

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010674:658596:658596658596659519924Clostridium botulinum B str. Eklund 17B, complete genomehypothetical protein2e-173608
NC_010001:1917456:191927519192751920270996Clostridium phytofermentans ISDg, complete genomehypothetical protein6e-67254
NC_013174:2712000:273063727306372731602966Jonesia denitrificans DSM 20603, complete genomemembrane protein2e-106385
NC_014246:496976:5136745136745146871014Mobiluncus curtisii ATCC 43063 chromosome, complete genomemembrane protein2e-65249
NC_014246:496976:5110075110075123711365Mobiluncus curtisii ATCC 43063 chromosome, complete genomehypothetical protein1e-28127
NC_013165:2700978:2700978270097827020811104Slackia heliotrinireducens DSM 20476, complete genomehypothetical protein3e-44179