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Query: NC_010723:3133302:3147705 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 3147705, End: 3148535, Length: 831

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012225:236490:253308253308254117810Brachyspira hyodysenteriae WA1, complete genomepyridoxamine kinase1e-28127
NC_017243:1323870:134217313421731342988816Brachyspira intermedia PWS/A chromosome, complete genomepyridoxamine kinase2e-28126
NC_010520:1586000:158637315863731587209837Clostridium botulinum A3 str. Loch Maree, complete genomepyridoxine kinase2e-42172
NC_013410:1651000:167525216752521676082831Fibrobacter succinogenes subsp. succinogenes S85 chromosome,phosphomethylpyrimidine kinase type-15e-75281
NC_009513:1065704:106570410657041066543840Lactobacillus reuteri F275, complete genomephosphomethylpyrimidine kinase3e-0652.8
NC_013192:519600:522189522189523001813Leptotrichia buccalis DSM 1135, complete genomephosphomethylpyrimidine kinase2e-0653.5
NC_015873:2260048:227560122756012276422822Megasphaera elsdenii DSM 20460, complete genomeputative pyridoxal kinase4e-75281
NC_014210:723719:741282741282742085804Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111 chromosome,phosphomethylpyrimidine kinase7e-0961.2
NC_016048:2907702:293291329329132933722810Oscillibacter valericigenes Sjm18-20, complete genomephosphomethylpyrimidine kinase7e-0961.2
NC_019960:1524338:152598215259821526800819Prevotella dentalis DSM 3688 chromosome 1, complete sequencepyridoxal/pyridoxine/pyridoxamine kinase4e-29128
NC_016628:537137:567998567998568858861Vibrio furnissii NCTC 11218 chromosome 2, complete sequencephosphomethylpyrimidine kinase3e-0858.9
NC_013457:979102:994942994942995802861Vibrio sp. Ex25 chromosome 2, complete genomephosphomethylpyrimidine kinase2e-0652.8