Pre_GI: BLASTP Hits

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Query: NC_010723:2231834:2243330 Clostridium botulinum E3 str. Alaska E43, complete genome

Start: 2243330, End: 2244466, Length: 1137

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was probably isolated from salmon eggs associated with a foodborne case of botulism in Alaska, however the exact details are not available. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010674:2435241:2445353244535324464831131Clostridium botulinum B str. Eklund 17B, complete genomeglycerate kinase 21e-179629
NC_009328:3504454:3507289350728935084431155Geobacillus thermodenitrificans NG80-2 chromosome, complete genomeglycerate kinase9e-109394
NC_015565:824448:8359778359778371131137Desulfotomaculum carboxydivorans CO-1-SRB chromosome, completeglycerate kinase1e-105383
NC_020207:1346579:1376788137678813779331146Enterococcus faecium NRRL B-2354, complete genomeGlycerate kinase3e-103375
NC_010498:3488513:3500461350046135016061146Escherichia coli SMS-3-5, complete genomeglycerate kinase3e-99362
NC_011751:3710786:3725565372556537267911227Escherichia coli UMN026 chromosome, complete genomeglycerate kinase I4e-99361
NC_011750:3768692:3783469378346937846951227Escherichia coli IAI39 chromosome, complete genomeglycerate kinase I4e-99361
NC_004741:3240909:3253237325323732544631227Shigella flexneri 2a str. 2457T, complete genomehypothetical protein2e-98359
NC_004337:3249791:3262119326211932633451227Shigella flexneri 2a str. 301, complete genomehypothetical protein2e-98359
NC_017328:3289853:3302181330218133034071227Shigella flexneri 2002017 chromosome, complete genomeglycerate kinase2e-98359
CU928145:3608917:3625593362559336268191227Escherichia coli 55989 chromosome, complete genomeglycerate kinase I2e-98359
CU928160:3344746:3356867335686733580931227Escherichia coli IAI1 chromosome, complete genomeglycerate kinase I2e-98359
NC_011748:3608917:3625593362559336268191227Escherichia coli 55989, complete genomeglycerate kinase I2e-98359
NC_011741:3344746:3356867335686733580931227Escherichia coli IAI1 chromosome, complete genomeglycerate kinase I2e-98359
NC_009801:3595001:3605502360550236066471146Escherichia coli E24377A, complete genomeglycerate kinase2e-98359
NC_011415:3523364:3538429353842935395741146Escherichia coli SE11 chromosome, complete genomeglycerate kinase I2e-98359
NC_007613:2981829:2993253299325329944791227Shigella boydii Sb227, complete genomehypothetical protein5e-98358
NC_013941:3884725:3899502389950239007281227Escherichia coli O55:H7 str. CB9615 chromosome, complete genomehypothetical protein5e-98358
NC_002695:3994970:4009860400986040110051146Escherichia coli O157:H7 str. Sakai, complete genomehypothetical protein5e-98358
CP002185:3475991:3488329348832934894741146Escherichia coli W, complete genomeglycerate kinase I5e-98358
NC_009800:3307123:3319245331924533203901146Escherichia coli HS, complete genomeglycerate kinase5e-98358
NC_010468:613812:6188956188956200401146Escherichia coli ATCC 8739, complete genomeGlycerate kinase5e-98358
NC_012759:3143455:3155795315579531569401146Escherichia coli BW2952 chromosome, complete genomeglycerate kinase5e-98358
NC_012947:630757:6358406358406369851146Escherichia coli 'BL21-Gold(DE3)pLysS AG' chromosome, completeglycerate kinase I5e-98358
CP002516:613462:6165186165186177441227Escherichia coli KO11, complete genomeglycerate kinase7e-98357
NC_016902:613462:6165186165186177441227Escherichia coli KO11FL chromosome, complete genomeglycerate kinase7e-98357
NC_010473:3354052:3366392336639233676181227Escherichia coli str. K-12 substr. DH10B, complete genomeglycerate kinase I6e-98357
NC_000913:3256307:3268647326864732698731227Escherichia coli K12, complete genomeglycerate kinase I6e-98357
AC_000091:3258377:3270480327048032717061227Escherichia coli W3110 DNA, complete genomeglycerate kinase I6e-98357
NC_012967:3191319:3203554320355432047801227Escherichia coli B str. REL606 chromosome, complete genomeglycerate kinase I6e-98357
NC_008258:3224721:3237049323704932382751227Shigella flexneri 5 str. 8401, complete genomehypothetical protein1e-97356
NC_009848:3582384:3594485359448535956241140Bacillus pumilus SAFR-032, complete genomeglycerate kinase8e-97354
NC_010658:3014371:3015352301535230164971146Shigella boydii CDC 3083-94, complete genomeglycerate kinase5e-96351
NC_008529:887008:8882908882908894381149Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365, completeGlycerate kinase7e-96350
NC_011184:2421687:2424238242423824253681131Vibrio fischeri MJ11 chromosome I, complete sequenceglycerate kinase4e-95348
NC_008054:899441:9007509007509018981149Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842, completeGlycerate kinase4e-95348
NC_007503:1111457:1129126112912611302801155Carboxydothermus hydrogenoformans Z-2901, complete genomeglycerate kinase 23e-94345
NC_012779:3570720:3585477358547735866131137Edwardsiella ictaluri 93-146, complete genomeglycerate kinase 11e-92340
NC_009901:3317068:3317068331706833182221155Shewanella pealeana ATCC 700345, complete genomeGlycerate kinase2e-91336
NC_014166:1008266:1015842101584210169991158Arcobacter nitrofigilis DSM 7299 chromosome, complete genomeglycerate kinase1e-90333
NC_017208:108134:1604791604791616241146Bacillus thuringiensis serovar chinensis CT-43 chromosome, completeglycerate kinase6e-90331
NC_014410:2609588:2619071261907126202071137Thermoanaerobacterium thermosaccharolyticum DSM 571 chromosome,glycerate kinase2e-89329
NC_015499:352934:3704113704113715831173Thermodesulfobium narugense DSM 14796 chromosome, complete genomeglycerate kinase6e-89327
NC_014171:109280:1587161587161598611146Bacillus thuringiensis BMB171 chromosome, complete genomeglycerate kinase9e-89327
NC_015555:2359000:2366604236660423677221119Thermoanaerobacterium xylanolyticum LX-11 chromosome, completeglycerate kinase2e-87322
NC_007492:3332839:3353040335304033541791140Pseudomonas fluorescens PfO-1, complete genomeGlycerate kinase5e-86318
NC_011593:1651635:1653470165347016546031134Bifidobacterium longum subsp. infantis ATCC 15697 chromosome,glycerate kinase6e-83308
NC_017219:1651425:1653260165326016544111152Bifidobacterium longum subsp. infantis ATCC 15697, complete genomeglycerate kinase8e-83307
NC_009078:142794:1628341628341640001167Burkholderia pseudomallei 1106a chromosome II, complete sequenceglycerate kinase1e-82306
NC_007435:1981164:2001363200136320025291167Burkholderia pseudomallei 1710b chromosome II, complete sequenceglycerate kinase 12e-82306
NC_006351:142788:1628161628161639821167Burkholderia pseudomallei K96243 chromosome 2, complete sequenceglycerate kinase 12e-82306
NC_014654:592582:5978905978905990381149Halanaerobium sp. 'sapolanicus' chromosome, complete genomeglycerate kinase8e-82304
NC_010623:1961685:2010979201097920121661188Burkholderia phymatum STM815 chromosome 2, complete sequenceGlycerate kinase1e-79297
NC_010498:4967724:4972272497227249734141143Escherichia coli SMS-3-5, complete genomeglycerate kinase GcxK1e-75283
NC_009615:3756196:3758330375833037594751146Parabacteroides distasonis ATCC 8503 chromosome, complete genomehypothetical protein1e-71270
NC_012472:2109719:2129812212981221309961185Bacillus cereus 03BB102, complete genomeconserved hypothetical protein TIGR000451e-68260
NC_008618:1487000:1487043148704314882451203Bifidobacterium adolescentis ATCC 15703, complete genomeglycerate kinase1e-68260
NC_015977:2309873:2316561231656123176881128Roseburia hominis A2-183 chromosome, complete genomehypothetical protein1e-68260
NC_014335:2009662:2029142202914220303261185Bacillus cereus biovar anthracis str. CI chromosome, completeglycerate kinase3e-68259
NC_015577:862659:8827348827348838761143Treponema azotonutricium ZAS-9 chromosome, complete genomeglycerate kinase2e-67256
NC_003888:2305901:2305901230590123071991299Streptomyces coelicolor A3(2), complete genomeglycerate kinase5e-67254
NC_019908:2496149:2516075251607525172141140Brachyspira pilosicoli P43/6/78 chromosome, complete genomeglycerate kinase2e-66253
NC_014330:697429:7013927013927025311140Brachyspira pilosicoli 95/1000 chromosome, complete genomeglycerate kinase2e-66253
NC_020134:301500:3102103102103113461137Clostridium stercorarium subsp. stercorarium DSM 8532, completeglycerate kinase GlxK2e-65249
NC_011992:2279752:2290120229012022913191200Acidovorax ebreus TPSY, complete genomeglycerate kinase6e-65248
NC_004369:256262:2589672589672601871221Corynebacterium efficiens YS-314, complete genomeputative glycerate kinase1e-56221
NC_015581:1791658:1813058181305818141911134Thioalkalimicrobium cyclicum ALM1 chromosome, complete genomeglycerate kinase1e-56220
NC_010545:2025000:2026553202655320277911239Corynebacterium urealyticum DSM 7109, complete genomeputative glycerate kinase1e-54214
NC_015859:1099919:1130131113013111312311101Corynebacterium variabile DSM 44702 chromosome, complete genomeglycerate kinase1e-54214
NC_016935:2347691:2378291237829123794481158Paenibacillus mucilaginosus 3016 chromosome, complete genomeglycerate kinase1e-51204
NC_015690:1818333:1848417184841718495741158Paenibacillus mucilaginosus KNP414 chromosome, complete genomeglycerate kinase1e-51204
NC_021175:597968:5986245986245997541131Streptococcus oligofermentans AS 1.3089, complete genomeglycerate kinase4e-50199
NC_013521:2924540:2926021292602129271781158Sanguibacter keddieii DSM 10542, complete genomeglycerate kinase4e-50198
NC_015656:1653450:1669849166984916710661218Frankia symbiont of Datisca glomerata chromosome, complete genomeglycerate kinase6e-47188
NC_015145:92397:1110341110341122031170Arthrobacter phenanthrenivorans Sphe3 chromosome, complete genomeglycerate kinase5e-44178
NC_013093:5734002:5740013574001357411461134Actinosynnema mirum DSM 43827, complete genomeglycerate kinase2e-40166
NC_011000:1262324:1290608129060812917651158Burkholderia cenocepacia J2315 chromosome 1, complete sequenceputative glycerate kinase7e-37154
NC_015514:2414617:2433546243354624347361191Cellulomonas fimi ATCC 484 chromosome, complete genomeglycerate kinase1e-35150
NC_015757:263938:2639382639382650561119Sulfobacillus acidophilus TPY chromosome, complete genomeglycerate kinase 27e-32138
NC_016884:256598:2565982565982577161119Sulfobacillus acidophilus DSM 10332 chromosome, complete genomeglycerate kinase7e-32138
NC_014334:369974:3862103862103873551146Lactobacillus casei str. Zhang chromosome, complete genomeglycerate kinase2e-31137
NC_017080:2379551:2381193238119323823201128Phycisphaera mikurensis NBRC 102666, complete genomeglycerate kinase2e-31136
NC_019673:1656680:1666964166696416679861023Saccharothrix espanaensis DSM 44229 complete genomeGlycerate kinase7e-30131
NC_015671:1540860:1544780154478015459581179Cellvibrio gilvus ATCC 13127 chromosome, complete genomeglycerate kinase8e-30131
NC_006361:2920028:2921917292191729230531137Nocardia farcinica IFM 10152, complete genomehypothetical protein9e-29128
NC_020302:146807:1629551629551639741020Corynebacterium halotolerans YIM 70093 = DSM 44683, completeglycerate kinase1e-23111
NC_017303:1454841:1473388147338814745781191Corynebacterium pseudotuberculosis I19 chromosome, complete genomeglycerate kinase8e-22104
NC_017317:1598925:1615662161566216168611200Corynebacterium ulcerans 809 chromosome, complete genomehypothetical protein2e-21103
NC_014151:2312000:2328173232817323293691197Cellulomonas flavigena DSM 20109 chromosome, complete genomeglycerate kinase1e-1894.4
NC_015723:589727:589727589727590386660Cupriavidus necator N-1 chromosome 2, complete sequenceglycerate kinase7e-0962