Pre_GI: BLASTP Hits

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Query: NC_010161:1949637:1949637 Bartonella tribocorum CIP 105476, complete genome

Start: 1949637, End: 1950062, Length: 426

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_020301:853267:875240875240875662423Bartonella vinsonii subsp. berkhoffii str. Winnie, complete genomeprophage protein1e-66251
NC_012751:1988280:200128420012842001712429Candidatus Hamiltonella defensa 5AT (Acyrthosiphon pisum), completehypothetical protein3e-1167.4
NC_002927:3827211:384743938474393847870432Bordetella bronchiseptica RB50, complete genomehypothetical protein7e-0856.2
NC_015388:1678000:169625816962581696899642Desulfobacca acetoxidans DSM 11109 chromosome, complete genomeprotein of unknown function DUF13201e-0755.5
NC_015172:3160249:318043131804313180880450Syntrophobotulus glycolicus DSM 8271 chromosome, complete genomeprotein of unknown function DUF13201e-0652.4
NC_015172:515557:538073538073538522450Syntrophobotulus glycolicus DSM 8271 chromosome, complete genomeprotein of unknown function DUF13201e-0652.4
NC_015172:2628128:265168426516842652133450Syntrophobotulus glycolicus DSM 8271 chromosome, complete genomeprotein of unknown function DUF13201e-0652.4
NC_015172:2986867:300621130062113006660450Syntrophobotulus glycolicus DSM 8271 chromosome, complete genomeprotein of unknown function DUF13201e-0652.4