Pre_GI: BLASTP Hits

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Query: NC_009882:100000:100236 Rickettsia rickettsii str. 'Sheila Smith', complete genome

Start: 100236, End: 100796, Length: 561

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This strain was isolated from from a patient with Rocky Mountain spotted fever. Causative agent for Rocky Mountain Spotted Fever. This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Rickettsia rickettsii was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016914:99184:100322100322100882561Rickettsia rickettsii str. Hino chromosome, complete genomeputative cytoplasmic protein1e-98358
NC_016913:1066790:106824210682421068802561Rickettsia rickettsii str. Brazil chromosome, complete genomeputative cytoplasmic protein1e-98358
NC_016909:100000:100264100264100824561Rickettsia rickettsii str. Arizona chromosome, complete genomeputative cytoplasmic protein1e-98358
NC_016908:100000:100269100269100829561Rickettsia rickettsii str. Colombia chromosome, complete genomeputative cytoplasmic protein1e-98358
NC_010263:100000:100235100235100795561Rickettsia rickettsii str. Iowa, complete genomehypothetical cytosolic protein1e-98358
NC_017044:80384:101173101173101733561Rickettsia parkeri str. Portsmouth chromosome, complete genomeputative cytoplasmic protein3e-96350
NC_012633:98000:980599805998619561Rickettsia africae ESF-5, complete genomehypothetical protein3e-96350
NC_017058:129474:129474129474130034561Rickettsia australis str. Cutlack chromosome, complete genomeputative cytoplasmic protein1e-94345
NC_009881:92929:940399403994644606Rickettsia akari str. Hartford, complete genomehypothetical protein6e-91332
NC_017066:57571:783207832078880561Rickettsia typhi str. TH1527 chromosome, complete genomeputative cytoplasmic protein1e-90332
NC_017062:61500:787377873779297561Rickettsia typhi str. B9991CWPP chromosome, complete genomeputative cytoplasmic protein1e-90332
NC_006142:57571:783207832078880561Rickettsia typhi str. Wilmington, complete genomehypothetical protein1e-90332
NC_012026:21385:428634286343480618Anaplasma marginale str. Florida, complete genomehypothetical protein8e-46182
NC_006831:211947:217752217752218417666Ehrlichia ruminantium str. Gardel, complete genomehypothetical protein2e-44178
NC_007799:186000:189220189220189861642Ehrlichia chaffeensis str. Arkansas, complete genomehypothetical protein6e-44176