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Query: NC_009698:1337383 Clostridium botulinum A str. Hall chromosome, complete genome

Start: 1337383, End: 1357599, Length: 20217

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A strain Hall was received at Fort Detrick from Harvard University in 1947. The strain is presumably one from Dr. Ivan Hall's collection, but the exact strain number has been lost. This strain produces high amounts of type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_012563:14640001464000148609922100Clostridium botulinum A2 str. Kyoto, complete genome09321BLASTN svgBLASTP svg
NC_010516:13820001382000140409922100Clostridium botulinum B1 str. Okra, complete genome06175BLASTN svgBLASTP svg
NC_010520:14279811427981145070222722Clostridium botulinum A3 str. Loch Maree, complete genome06064BLASTN svgBLASTP svg
NC_014328:2990790*2990790303209941310Clostridium ljungdahlii ATCC 49587 chromosome, complete genome4e-79303BLASTN svgBLASTP svg
NC_014328:30666283066628308784821221Clostridium ljungdahlii ATCC 49587 chromosome, complete genome4e-45190BLASTN svgBLASTP svg
NC_013316:26231992623199264226019062Clostridium difficile R20291, complete genome4e-45190BLASTN svgBLASTP svg
NC_008262:2649289*2649289270467655388Clostridium perfringens SM101, complete genome5e-26127BLASTN svgBLASTP svg
NC_019978:21893942189394220827218879Halobacteroides halobius DSM 5150, complete genome5e-23117BLASTN svgBLASTP svg
NC_014614:1259236*1259236127792218687Clostridium sticklandii, complete genome4e-20107BLASTN svgBLASTP svg
NC_010674:192951*19295121941726467Clostridium botulinum B str. Eklund 17B, complete genome6e-1383.8BLASTN svgBLASTP svg
NC_014150:3085013*3085013310947924467Brachyspira murdochii DSM 12563 chromosome, complete genome6e-1073.8BLASTN svgBLASTP svg
NC_018604:78957578957581008920515Brachyspira pilosicoli WesB complete genome1e-0869.9BLASTN svgBLASTP svg
NC_018607:66269766269768184019144Brachyspira pilosicoli B2904 chromosome, complete genome1e-0869.9BLASTN svgBLASTP svg
NC_014330:20261932026193204718920997Brachyspira pilosicoli 95/1000 chromosome, complete genome1e-0869.9BLASTN svgBLASTP svg
NC_003869:18126421812642183146018819Thermoanaerobacter tengcongensis MB4, complete genome1e-0869.9BLASTN svgBLASTP svg
NC_019908:12256901225690124895123262Brachyspira pilosicoli P43/6/78 chromosome, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_018866:15425215425217209917848Dehalobacter sp. DCA chromosome, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_014328:180482*18048220427623795Clostridium ljungdahlii ATCC 49587 chromosome, complete genome9e-0660BLASTN svgBLASTP svg