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Query: NC_009698:3647955:3669052 Clostridium botulinum A str. Hall chromosome, complete genome

Start: 3669052, End: 3669127, Length: 76

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A strain Hall was received at Fort Detrick from Harvard University in 1947. The strain is presumably one from Dr. Ivan Hall's collection, but the exact strain number has been lost. This strain produces high amounts of type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017294:403422:42172942172942180476Candidatus Arthromitus sp. SFB-mouse-Yit, complete genometRNA-Pro3e-0650.8
NC_010723:420025:42545142545142552676Clostridium botulinum E3 str. Alaska E43, complete genometRNA-Pro3e-0650.4
NC_008261:2770468:27899472789947279002276Clostridium perfringens ATCC 13124, complete genometRNA-Pro3e-0650.4
NC_008261:2770468:27888722788872278894776Clostridium perfringens ATCC 13124, complete genometRNA-Pro3e-0650.4
NC_008262:2433979:24510982451098245117376Clostridium perfringens SM101, complete genometRNA-Pro3e-0650.4
NC_008262:297960:32306932306932314476Clostridium perfringens SM101, complete genometRNA-Pro3e-0650.4
NC_010674:426256:43170643170643178176Clostridium botulinum B str. Eklund 17B, complete genometRNA-Pro3e-0650.4