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Query: NC_009697:3291500 Clostridium botulinum A str. ATCC 19397 chromosome, complete

Start: 3291500, End: 3309249, Length: 17750

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A ATCC 19397 (NCTC 4587, NCTC 7272) is a stock, type A toxin-producing, laboratory strain of known toxicity. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_012563:3556763*3556763357533918577Clostridium botulinum A2 str. Kyoto, complete genome03435BLASTN svgBLASTP svg
NC_010674:24171992417199243509917901Clostridium botulinum B str. Eklund 17B, complete genome4e-1177.8BLASTN svgBLASTP svg
NC_010516:3368951*3368951339250323553Clostridium botulinum B1 str. Okra, complete genome03380BLASTN svgBLASTP svg
NC_014328:3747973*3747973377009922127Clostridium ljungdahlii ATCC 49587 chromosome, complete genome2e-93351BLASTN svgBLASTP svg
NC_008262:20256992025699204408118383Clostridium perfringens SM101, complete genome2e-49204BLASTN svgBLASTP svg
NC_003366:21431732143173216513121959Clostridium perfringens str. 13, complete genome9e-46192BLASTN svgBLASTP svg
NC_020291:2873000*2873000289187618877Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome9e-126458BLASTN svgBLASTP svg
NC_020291:11498871149887117209922213Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome1e-29139BLASTN svgBLASTP svg
NC_003454:63500*6350010726843769Fusobacterium nucleatum subsp. nucleatum ATCC 25586, complete9e-0969.9BLASTN svgBLASTP svg
NC_003454:618290*61829063831520026Fusobacterium nucleatum subsp. nucleatum ATCC 25586, complete5e-0763.9BLASTN svgBLASTP svg
NC_019978:2071435*2071435209759326159Halobacteroides halobius DSM 5150, complete genome9e-0969.9BLASTN svgBLASTP svg
NC_002976:707827*70782773065222826Staphylococcus epidermidis RP62A, complete genome8e-0660BLASTN svgBLASTP svg
NC_014209:1487699*1487699151184724149Thermoanaerobacter mathranii subsp. mathranii str. A3 chromosome,5e-0763.9BLASTN svgBLASTP svg