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Query: NC_009495:2056546:2076811 Clostridium botulinum A str. ATCC 3502 chromosome, complete genome

Start: 2076811, End: 2078274, Length: 1464

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a well-studied Hall strain that produces type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009698:1985404:2005669200566920071321464Clostridium botulinum A str. Hall chromosome, complete genomeABC transporter permease0928
NC_012563:2203037:2223302222330222247651464Clostridium botulinum A2 str. Kyoto, complete genomeABC transporter, permease protein0927
NC_008618:1095000:1110755111075511121221368Bifidobacterium adolescentis ATCC 15703, complete genomeABC-type transporter similar to Vex38e-1995.5
NC_009089:2150062:21362292136229218593049702Clostridium difficile 630, complete genome3e-1893.6
NC_014218:882118:8935388935388949141377Arcanobacterium haemolyticum DSM 20595 chromosome, complete genomeprotein of unknown function DUF2144e-1583.2
NC_014218:882118:8915958915958928721278Arcanobacterium haemolyticum DSM 20595 chromosome, complete genomeprotein of unknown function DUF2147e-1582.4
NC_008618:1095000:1112128111212811133421215Bifidobacterium adolescentis ATCC 15703, complete genomeATP binding protein of ABC transporter similar to Vex11e-1378.6
NC_013714:2086526:2152731215273121539541224Bifidobacterium dentium Bd1, complete genomeATP-binding protein of ABC transporter system VexP16e-1169.3
NC_013714:2086526:2153951215395121553211371Bifidobacterium dentium Bd1, complete genomeATP-binding protein of ABC transporter system VexP31e-0861.6
NC_017219:2646157:2671612267161226731021491Bifidobacterium longum subsp. infantis ATCC 15697, complete genomeABC transporter permease2e-0654.7
NC_011593:2650156:2675611267561126771011491Bifidobacterium longum subsp. infantis ATCC 15697 chromosome,hypothetical protein2e-0654.7