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Query: NC_009495:2056546:2065268 Clostridium botulinum A str. ATCC 3502 chromosome, complete genome

Start: 2065268, End: 2065708, Length: 441

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a well-studied Hall strain that produces type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009698:1985404:199412619941261994566441Clostridium botulinum A str. Hall chromosome, complete genomeMOSC domain-containing protein3e-79293
NC_009697:1985187:199390919939091994349441Clostridium botulinum A str. ATCC 19397 chromosome, completeMOSC domain-containing protein3e-79293
NC_012563:2203037:221175922117592212199441Clostridium botulinum A2 str. Kyoto, complete genomeMOSC domain protein3e-79293
NC_010516:2064027:207334420733442073784441Clostridium botulinum B1 str. Okra, complete genomeMOSC domain protein1e-78291
NC_017297:2114222:212351421235142123954441Clostridium botulinum F str. 230613 chromosome, complete genomeMOSC domain-containing protein7e-78288
NC_009699:2116500:212341221234122123852441Clostridium botulinum F str. Langeland chromosome, complete genomeMOSC domain-containing protein7e-78288
NC_010520:2171584:218284921828492183289441Clostridium botulinum A3 str. Loch Maree, complete genomeMOSC domain protein3e-77286
NC_009617:2304390:231542523154252315856432Clostridium beijerinckii NCIMB 8052 chromosome, complete genomeMOSC domain-containing protein4e-61233
NC_010003:449192:450740450740451174435Petrotoga mobilis SJ95, complete genomeMOSC domain containing protein2e-52203
NC_014624:1349950:136093413609341361374441Eubacterium limosum KIST612 chromosome, complete genomeMOSC domain-containing protein1e-50198
NC_021182:1009526:102285910228591023305447Clostridium pasteurianum BC1, complete genomehypothetical protein1e-50197
NC_014632:1404000:141985514198551420304450Ilyobacter polytropus DSM 2926 chromosome, complete genomeMOSC domain-containing protein5e-50196
NC_014220:587826:587826587826588269444Syntrophothermus lipocalidus DSM 12680 chromosome, complete genomeMOSC domain containing protein3e-45180
NC_007517:2342607:235823323582332358691459Geobacter metallireducens GS-15, complete genomeMOSC3e-42170
NC_007644:2205599:223135622313562231793438Moorella thermoacetica ATCC 39073, complete genomeMOSC2e-39160
NC_011830:1504497:150997315099731510407435Desulfitobacterium hafniense DCB-2, complete genomeMOSC domain containing protein7e-39159
NC_018870:115982:161575161575162036462Thermacetogenium phaeum DSM 12270 chromosome, complete genomeMOSC domain-containing protein3e-37153
NC_015574:1046500:106539810653981065853456Methanobacterium sp. SWAN-1 chromosome, complete genomeMOSC domain-containing protein6e-35145
NC_019978:1244000:125965412596541260574921Halobacteroides halobius DSM 5150, complete genomemolybdenum cofactor biosynthesis protein MoaC4e-34143
NC_015672:101878:108262108262109191930Flexistipes sinusarabici DSM 4947 chromosome, complete genomemolybdenum cofactor synthesis domain-containing protein1e-33141
NC_008262:1950205:195787219578721958300429Clostridium perfringens SM101, complete genomeMOSC domain, putative9e-33138
NC_003366:2057656:206856320685632068991429Clostridium perfringens str. 13, complete genomehypothetical protein9e-33138
NC_019908:463281:482065482065482514450Brachyspira pilosicoli P43/6/78 chromosome, complete genomemolybdenum cofactor sulfurase2e-28124
NC_018607:1505908:150590815059081506357450Brachyspira pilosicoli B2904 chromosome, complete genomemolybdenum cofactor sulfurase2e-28124
NC_014330:169862:175338175338175787450Brachyspira pilosicoli 95/1000 chromosome, complete genomeputative molybdenum cofactor sulfurase2e-28124
NC_018604:1292889:130656013065601307009450Brachyspira pilosicoli WesB complete genomeputative molybdenum cofactor sulfurase2e-28124
NC_015499:1466794:148451914845191484968450Thermodesulfobium narugense DSM 14796 chromosome, complete genomeMOSC domain containing protein7e-1269.3
NC_011894:6516856:6529650652965065314101761Methylobacterium nodulans ORS 2060, complete genomeMOSC domain containing protein2e-0754.3
NC_019897:329945:373241373241373804564Thermobacillus composti KWC4 chromosome, complete genomehypothetical protein5e-0649.7