Pre_GI: BLASTP Hits

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Query: NC_009089:1329826:1350200 Clostridium difficile 630, complete genome

Start: 1350200, End: 1350484, Length: 285

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017179:1197763:121813712181371218421285Clostridium difficile BI1, complete genomecell division topological specificity factor MinE4e-48189
NC_013315:1187986:120836012083601208644285Clostridium difficile CD196 chromosome, complete genomecell division topological specificity factor MinE4e-48189
NC_009633:2350892:236514123651412365425285Alkaliphilus metalliredigens QYMF chromosome, complete genomecell division topological specificity factor MinE9e-26115
NC_017295:1375180:139459313945931394865273Clostridium acetobutylicum EA 2018 chromosome, complete genomeCell division topological specificity factor MinE2e-1891.3
NC_015687:1377367:139678013967801397052273Clostridium acetobutylicum DSM 1731 chromosome, complete genomeCell division topological specificity factor2e-1891.3
NC_021182:2160580:217632321763232176592270Clostridium pasteurianum BC1, complete genomecell division topological specificity factor MinE3e-1890.5
NC_003030:1375764:139517213951721395522351Clostridium acetobutylicum ATCC 824, complete genome1e-1582
NC_020291:5778999:579695257969525797221270Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomecell division topological specificity factor MinE3e-1580.5
NC_010516:3234791:324811132481113248374264Clostridium botulinum B1 str. Okra, complete genomecell division topological specificity factor MinE4e-1580.1
NC_012563:3416509:342659434265943426857264Clostridium botulinum A2 str. Kyoto, complete genomecell division topological specificity factor MinE4e-1580.1
NC_009698:3046833:306014230601423060405264Clostridium botulinum A str. Hall chromosome, complete genomecell division topological specificity factor MinE4e-1580.1
NC_009699:3217315:323063532306353230898264Clostridium botulinum F str. Langeland chromosome, complete genomecell division topological specificity factor MinE4e-1580.1
NC_014328:794000:808058808058808324267Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative septum formation topological specificity factor2e-1477.4
NC_018515:4334240:436903243690324369325294Desulfosporosinus meridiei DSM 13257 chromosome, complete genomecell division topological specificity factor MinE3e-1477.4
NC_009617:588897:599925599925600194270Clostridium beijerinckii NCIMB 8052 chromosome, complete genomecell division topological specificity factor MinE9e-1475.5
NC_016584:5388500:540311854031185403396279Desulfosporosinus orientis DSM 765 chromosome, complete genomecell division topological specificity factor MinE9e-1372.4
NC_007513:1764739:178632017863201786607288Synechococcus sp. CC9902, complete genomeSeptum formation topological specificity factor MinE3e-0960.8
NC_011297:1224749:123300412330041233246243Dictyoglomus thermophilum H-6-12, complete genomecell division topological specificity factor MinE3e-0857
NC_011661:1411383:141326614132661413508243Dictyoglomus turgidum DSM 6724, complete genomecell division topological specificity factor MinE2e-0754.7