Pre_GI: BLASTP Hits

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Query: NC_009089:1329826:1348678 Clostridium difficile 630, complete genome

Start: 1348678, End: 1349361, Length: 684

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017179:1197763:121661512166151217298684Clostridium difficile BI1, complete genomeseptum site-determining protein2e-125447
NC_013315:1187986:120683812068381207521684Clostridium difficile CD196 chromosome, complete genomeseptum site-determining protein2e-125447
NC_013316:1186156:120445412044541205137684Clostridium difficile R20291, complete genomeseptum site-determining protein2e-125447
NC_009633:2350892:236366623636662364298633Alkaliphilus metalliredigens QYMF chromosome, complete genomeseptum site-determining protein MinC8e-30130
NC_009617:588897:598430598430599089660Clostridium beijerinckii NCIMB 8052 chromosome, complete genomeseptum formation inhibitor4e-1995.1
NC_003030:1375764:139337213933721394007636Clostridium acetobutylicum ATCC 824, complete genomeseptum formation inhibitor1e-1893.2
NC_015687:1377367:139497513949751395610636Clostridium acetobutylicum DSM 1731 chromosome, complete genomeseptum formation inhibitor1e-1893.2
NC_017295:1375180:139278813927881393423636Clostridium acetobutylicum EA 2018 chromosome, complete genomeseptum formation inhibitor1e-1893.2
NC_010516:3234791:324920332492033249832630Clostridium botulinum B1 str. Okra, complete genomeseptum site-determining protein MinC2e-1892.4
NC_009699:3217315:323172732317273232356630Clostridium botulinum F str. Langeland chromosome, complete genomeseptum formation inhibitor4e-1891.3
NC_012563:3416509:342768634276863428315630Clostridium botulinum A2 str. Kyoto, complete genomeseptum site-determining protein MinC4e-1891.3
NC_009698:3046833:306123430612343061863630Clostridium botulinum A str. Hall chromosome, complete genomeseptum formation inhibitor6e-1890.9
NC_021182:2160580:217485721748572175489633Clostridium pasteurianum BC1, complete genomeseptum site-determining protein MinC1e-1789.7
NC_014328:794000:806378806378807010633Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative septum site-determining protein MinC6e-1787.4
NC_020291:5778999:579805957980595798721663Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeputative septum site-determining protein MinC8e-1787
NC_016584:5388500:540425754042575404937681Desulfosporosinus orientis DSM 765 chromosome, complete genomeseptum site-determining protein MinC1e-1686.7
NC_018515:4334240:437018743701874370864678Desulfosporosinus meridiei DSM 13257 chromosome, complete genomeseptum site-determining protein MinC1e-1583.6
NC_010184:4287999:429198442919844292670687Bacillus weihenstephanensis KBAB4, complete genomeseptum site-determining protein MinC7e-1477.4
NC_006274:4295730:430055243005524301238687Bacillus cereus E33L, complete genomeseptum formation inhibitor4e-1374.7
NC_005957:4244019:424569942456994246385687Bacillus thuringiensis serovar konkukian str. 97-27, completeseptum formation inhibitor4e-1374.7
NC_005945:4251789:425661142566114257297687Bacillus anthracis str. Sterne, complete genomeseptum formation inhibitor4e-1374.7
NC_007530:4251773:425623942562394256925687Bacillus anthracis str. 'Ames Ancestor', complete genomeseptum formation inhibitor4e-1374.7
NC_014335:4181710:418682741868274187513687Bacillus cereus biovar anthracis str. CI chromosome, completeseptum formation inhibitor4e-1374.7
NC_003997:4252000:425611242561124256798687Bacillus anthracis str. Ames, complete genomeseptum formation inhibitor4e-1374.7
NC_003909:4209385:420938542093854210071687Bacillus cereus ATCC 10987, complete genomeseptum formation inhibitor4e-1374.7
NC_012472:4255729:426084642608464261532687Bacillus cereus 03BB102, complete genomeseptum site-determining protein MinC4e-1374.7
NC_011658:4243561:424609442460944246780687Bacillus cereus AH187 chromosome, complete genomeseptum formation inhibitor4e-1374.7
NC_011969:4140000:414401841440184144704687Bacillus cereus Q1 chromosome, complete genomeseptum formation inhibitor4e-1374.7
NC_012659:4252000:425613942561394256825687Bacillus anthracis str. A0248, complete genomeseptum formation inhibitor4e-1374.7
NC_016771:4195888:419987741998774200563687Bacillus cereus NC7401, complete genomeseptum site-determining protein MinC4e-1374.7
NC_017200:4267408:426908842690884269774687Bacillus thuringiensis serovar finitimus YBT-020 chromosome,septum formation inhibitor4e-1374.7
NC_019897:2645404:264735526473552648017663Thermobacillus composti KWC4 chromosome, complete genomeseptum formation inhibitor4e-1271.6
NC_015557:1232772:125678012567801257373594Hydrogenobaculum sp. 3684 chromosome, complete genomeseptum site-determining protein MinC7e-1270.9
NC_015587:1232642:125665012566501257243594Hydrogenobaculum sp. SHO chromosome, complete genomeseptum site-determining protein minC7e-1270.9
NC_020411:1232962:125697512569751257568594Hydrogenobaculum sp. HO, complete genomeseptum site-determining protein MinC7e-1270.9
NC_011126:1241655:126597412659741266567594Hydrogenobaculum sp. Y04AAS1, complete genomeseptum site-determining protein MinC2e-1169.3
NC_015161:758929:763425763425764066642Deinococcus proteolyticus MRP chromosome, complete genomeseptum site-determining protein minC4e-1168.6
NC_007513:1764739:178478617847861785445660Synechococcus sp. CC9902, complete genomepossible septum site-determining protein5e-1167.8
NC_011661:1411383:141430814143081414916609Dictyoglomus turgidum DSM 6724, complete genomeSeptum formation inhibitor MinC1e-1067
NC_012785:20454:476744767448330657Kosmotoga olearia TBF 19.5.1, complete genomeseptum site-determining protein MinC2e-1065.9
NC_009828:1530732:154551715455171546158642Thermotoga lettingae TMO, complete genomeseptum site-determining protein MinC7e-1064.3
NC_011297:1224749:123404612340461234654609Dictyoglomus thermophilum H-6-12, complete genomeseptum site-determining protein MinC1e-0859.7