Pre_GI: BLASTP Hits

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Query: NC_009089:1329826:1344188 Clostridium difficile 630, complete genome

Start: 1344188, End: 1345087, Length: 900

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017179:1197763:121213112121311213024894Clostridium difficile BI1, complete genomeputative rod shape-determining protein precursor2e-153541
NC_013315:1187986:120235412023541203247894Clostridium difficile CD196 chromosome, complete genomerod shape-determining protein2e-153541
NC_013316:1186156:119997011999701200863894Clostridium difficile R20291, complete genomeputative rod shape-determining protein precursor2e-153541
NC_009633:2350892:235931823593182360160843Alkaliphilus metalliredigens QYMF chromosome, complete genomerod shape-determining protein MreC8e-31134
NC_009617:588897:593149593149593997849Clostridium beijerinckii NCIMB 8052 chromosome, complete genomerod shape-determining protein MreC5e-2098.6
NC_009698:3046833:306533430653343066179846Clostridium botulinum A str. Hall chromosome, complete genomerod shape-determining protein MreC1e-1997.1
NC_010516:3234791:325330332533033254148846Clostridium botulinum B1 str. Okra, complete genomerod shape-determining protein MreC2e-1996.7
NC_009699:3217315:323582732358273236672846Clostridium botulinum F str. Langeland chromosome, complete genomerod shape-determining protein MreC2e-1996.7
NC_012563:3416509:343178634317863432643858Clostridium botulinum A2 str. Kyoto, complete genomerod shape-determining protein MreC2e-1893.6
NC_014328:794000:802055802055802918864Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative rod shape-determining protein MreC2e-1789.7
NC_009706:830461:867121867121867981861Clostridium kluyveri DSM 555 chromosome, complete genomerod shape-determining protein MreC1e-1480.5
NC_021182:2160580:216675621667562167601846Clostridium pasteurianum BC1, complete genomerod shape-determining protein MreC3e-1479.3
NC_017295:1375180:138248413824841383335852Clostridium acetobutylicum EA 2018 chromosome, complete genomeShape-determining protein mreC4e-1479
NC_015687:1377367:138467113846711385522852Clostridium acetobutylicum DSM 1731 chromosome, complete genomerod shape-determining protein MreC4e-1479
NC_003030:1375764:138306813830681383919852Clostridium acetobutylicum ATCC 824, complete genomeShape-determining protein mreC4e-1479
NC_018515:4334240:437442543744254375291867Desulfosporosinus meridiei DSM 13257 chromosome, complete genomerod shape-determining protein MreC8e-1374.7
NC_016584:5388500:540771054077105408579870Desulfosporosinus orientis DSM 765 chromosome, complete genomerod shape-determining protein MreC2e-1273.6
NC_015437:438538:4673824673824684581077Selenomonas sputigena ATCC 35185 chromosome, complete genomerod shape-determining protein MreC7e-1271.2
NC_007963:2512478:251247825124782513431954Chromohalobacter salexigens DSM 3043, complete genomerod shape-determining protein MreC6e-1168.2
NC_010184:4287999:429326642932664294117852Bacillus weihenstephanensis KBAB4, complete genomerod shape-determining protein MreC1e-1067.4
NC_003909:4209385:421066742106674211518852Bacillus cereus ATCC 10987, complete genomerod shape-determining protein MreC1e-1067.4
NC_007759:623116:624333624333625166834Syntrophus aciditrophicus SB, complete genomerod shape-determining protein2e-1066.6
NC_012472:4255729:426212842621284262979852Bacillus cereus 03BB102, complete genomerod shape-determining protein MreC4e-1065.5
NC_014335:4181710:418810941881094188960852Bacillus cereus biovar anthracis str. CI chromosome, completerod shape-determining protein MreC4e-1065.5
NC_005957:4244019:424698142469814247832852Bacillus thuringiensis serovar konkukian str. 97-27, completerod shape-determining protein9e-1064.3
NC_017200:4267408:427037042703704271221852Bacillus thuringiensis serovar finitimus YBT-020 chromosome,rod shape-determining protein MreC2e-0963.2
NC_016771:4195888:420115942011594202010852Bacillus cereus NC7401, complete genomerod shape-determining protein MreC2e-0963.2
NC_011969:4140000:414530041453004146151852Bacillus cereus Q1 chromosome, complete genomerod shape-determining protein mrec2e-0963.2
NC_011658:4243561:424737642473764248227852Bacillus cereus AH187 chromosome, complete genomerod shape-determining protein MreC2e-0963.2
NC_006274:4295730:430183443018344302685852Bacillus cereus E33L, complete genomerod shape-determining protein4e-0962.4
NC_007530:4251773:425752142575214258372852Bacillus anthracis str. 'Ames Ancestor', complete genomerod shape-determining protein mrec1e-0860.8
NC_005945:4251789:425789342578934258744852Bacillus anthracis str. Sterne, complete genomerod shape-determining protein MreC1e-0860.8
NC_003997:4252000:425739442573944258245852Bacillus anthracis str. Ames, complete genomerod shape-determining protein MreC1e-0860.8
NC_012659:4252000:425742142574214258272852Bacillus anthracis str. A0248, complete genomerod shape-determining protein MreC1e-0860.8
NC_013928:9494:235382353824356819Streptococcus mutans NN2025, complete genomecell shape-determining protein1e-0860.8
NC_011565:750168:756399756399757244846Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2,rod shape-determining protein MreC5e-0858.9
NC_014171:4317520:431808043180804318850771Bacillus thuringiensis BMB171 chromosome, complete genomerod shape-determining protein mreC9e-0857.8
NC_016913:83988:850318503185870840Rickettsia rickettsii str. Brazil chromosome, complete genomerod shape-determining protein MreC2e-0756.6
NC_011296:1750771:176900017690001769764765Thermodesulfovibrio yellowstonii DSM 11347, complete genomerod shape-determining protein MreC2e-0756.6
NC_019897:2645404:264860826486082649498891Thermobacillus composti KWC4 chromosome, complete genomerod shape-determining protein MreC4e-0755.8
NC_016050:1088223:110818511081851109024840Rickettsia japonica YH, complete genomerod shape-determining protein mreC7e-0754.7
NC_015496:1857900:188261418826141883459846Krokinobacter diaphorus 4H-3-7-5 chromosome, complete genomerod shape-determining protein MreC2e-0653.1
NC_015577:1974821:199481319948131995697885Treponema azotonutricium ZAS-9 chromosome, complete genomerod shape-determining protein MreC3e-0652.8
NC_017042:1206000:120719612071961208035840Rickettsia rhipicephali str. 3-7-female6-CWPP chromosome, completerod shape-determining protein MreC5e-0652