Pre_GI: BLASTP Hits

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Query: NC_009089:1329826:1340568 Clostridium difficile 630, complete genome

Start: 1340568, End: 1341545, Length: 978

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017179:1197763:120851112085111209482972Clostridium difficile BI1, complete genomeelectron transport complex protein1e-166585
NC_013315:1187986:119873411987341199705972Clostridium difficile CD196 chromosome, complete genomeelectron transport complex protein1e-166585
NC_013316:1186156:119635011963501197321972Clostridium difficile R20291, complete genomeelectron transport complex protein1e-166585
NC_009633:2350892:235497923549792355965987Alkaliphilus metalliredigens QYMF chromosome, complete genomeRnfABCDGE type electron transport complex subunit B3e-88325
NC_014632:11925:2504825048260521005Ilyobacter polytropus DSM 2926 chromosome, complete genomeRnfABCDGE type electron transport complex subunit B9e-70263
NC_009697:419443:426289426289427122834Clostridium botulinum A str. ATCC 19397 chromosome, completeferredoxin6e-57221
NC_010718:517473:526905526905527711807Natranaerobius thermophilus JW/NM-WN-LF, complete genomeelectron transport complex, RnfABCDGE type, B subunit4e-50198
NC_011661:1100576:111777711177771118577801Dictyoglomus turgidum DSM 6724, complete genomeelectron transport complex, RnfABCDGE type, B subunit3e-47189
NC_014253:1954024:197387419738741974746873Methanohalobium evestigatum Z-7303 chromosome, complete genomeRnfABCDGE type electron transport complex subunit B4e-47188
NC_007955:1464000:147010614701061470903798Methanococcoides burtonii DSM 6242, complete genomeelectron transport complex, RnfABCDGE type, B subunit3e-44179
NC_020291:744329:750862750862751668807Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeelectron transport complex protein, subunit B1e-43177
NC_006138:857692:872035872035872910876Desulfotalea psychrophila LSv54, complete genomeferredoxin3e-41169
NC_014150:648868:664240664240665079840Brachyspira murdochii DSM 12563 chromosome, complete genomeelectron transport complex, RnfABCDGE type, B subunit5e-35148
NC_018607:2032566:204834120483412049162822Brachyspira pilosicoli B2904 chromosome, complete genomeferredoxin4e-31135
NC_018604:838932:853215853215854036822Brachyspira pilosicoli WesB complete genomeferredoxin1e-30134
NC_020409:135699:1544871544871565922106Desulfovibrio piezophilus str. nov C1TLV30 chromosome, complete4Fe-4S ferredoxin iron-sulfur binding domain protein2e-27123
NC_013887:245236:275858275858276640783Methanocaldococcus sp. FS406-22 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein3e-1686.3
NC_007681:1608223:1617531161753116188861356Methanosphaera stadtmanae DSM 3091, complete genomeEhbK4e-1685.5
NC_000909:446364:455134455134455886753Methanocaldococcus jannaschii DSM 2661, complete genomepolyferredoxin (mvhB)7e-1581.6
NC_014011:1264165:128735912873591288021663Aminobacterium colombiense DSM 12261 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein8e-1581.6
NC_013407:1478811:1489190148919014903651176Methanocaldococcus vulcanius M7, complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein7e-1478.2
NC_003551:415803:426513426513427271759Methanopyrus kandleri AV19, complete genomeFerredoxin7e-1478.2
NC_015636:832224:8392688392688404281161Methanothermococcus okinawensis IH1 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain-containing protein9e-1477.8
NC_015574:2262742:2269752226975222711131362Methanobacterium sp. SWAN-1 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain-containing protein1e-1377.4
NC_015574:1046500:104863310486331049397765Methanobacterium sp. SWAN-1 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain-containing protein2e-1376.6
NC_014222:1411155:1421542142154214227291188Methanococcus voltae A3 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein3e-1376.3
NC_013887:189400:1994071994072005761170Methanocaldococcus sp. FS406-22 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein4e-1375.9
NC_013887:812091:8230758230758242501176Methanocaldococcus sp. FS406-22 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein4e-1375.9
NC_015562:1189111:1201006120100612021991194Methanotorris igneus Kol 5 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain-containing protein1e-1274.3
NC_009135:1654131:1665790166579016669771188Methanococcus maripaludis C5, complete genome4Fe-4S ferredoxin, iron-sulfur binding domain protein4e-1272.4
NC_013156:226215:2355912355912367631173Methanocaldococcus fervens AG86, complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein5e-1272
NC_015636:1061736:107467510746751075445771Methanothermococcus okinawensis IH1 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain-containing protein5e-1272
NC_009975:917337:9285489285489297351188Methanococcus maripaludis C6, complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein8e-1271.2
NC_009637:920423:9272049272049283911188Methanococcus maripaludis C7 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain-containing protein2e-1170.1
NC_009634:1002295:1009763100976310109501188Methanococcus vannielii SB chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain-containing protein3e-1169.7
NC_015216:1278706:1278706127870612800881383Methanobacterium sp. AL-21 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain-containing protein4e-1169.3
NC_005791:1626448:1632705163270516338561152Methanococcus maripaludis S2, complete genomepolyferredoxin, associated with F420-non-reducing hydrogenase5e-1168.9
NC_000909:1123161:1134586113458611357701185Methanocaldococcus jannaschii DSM 2661, complete genomepolyferredoxin (mvhB)5e-1168.9
NC_015636:1061736:1072806107280610740861281Methanothermococcus okinawensis IH1 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain-containing protein5e-1168.6
NC_009515:1409912:1435222143522214363191098Methanobrevibacter smithii ATCC 35061, complete genometungsten formylmethanofuran dehydrogenase, subunit F, FwdF7e-1168.6
NC_009635:94937:1028641028641040151152Methanococcus aeolicus Nankai-3 chromosome, complete genome4Fe-4S ferredoxin7e-1168.2
NC_003551:415803:4276864276864288251140Methanopyrus kandleri AV19, complete genomeFerredoxin1e-1067.8
NC_009635:1283830:1287142128714212883381197Methanococcus aeolicus Nankai-3 chromosome, complete genome4Fe-4S ferredoxin1e-1067.4
NC_014122:341365:3498593498593510371179Methanocaldococcus infernus ME chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein2e-1067
NC_009135:620312:6268086268086280011194Methanococcus maripaludis C5, complete genome4Fe-4S ferredoxin, iron-sulfur binding domain protein2e-1067
NC_015562:899030:9373779373779385821206Methanotorris igneus Kol 5 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain-containing protein2e-1066.6
NC_013887:245236:276610276610277101492Methanocaldococcus sp. FS406-22 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein2e-1066.6
NC_015636:175660:183340183340183942603Methanothermococcus okinawensis IH1 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain-containing protein5e-1065.5
NC_003551:415803:427268427268427711444Methanopyrus kandleri AV19, complete genomeFerredoxin6e-1065.5
NC_015574:143000:1473171473171483811065Methanobacterium sp. SWAN-1 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain-containing protein2e-0963.9
NC_009515:1481051:1484584148458414858221239Methanobrevibacter smithii ATCC 35061, complete genomeenergy-converting hydrogenase B, subunit K, EhbK1e-0963.9
NC_015216:2548057:2556787255678725578301044Methanobacterium sp. AL-21 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain-containing protein2e-0963.5
NC_009634:53555:6868468684698771194Methanococcus vannielii SB chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain-containing protein2e-0963.5
NC_015562:222000:2275442275442289921449Methanotorris igneus Kol 5 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain-containing protein2e-0963.5
NC_014408:1193239:120920212092021210200999Methanothermobacter marburgensis str. Marburg chromosome, completetungsten containing formylmethanofuran dehydrogenase, subunit F related protein3e-0962.8
NC_014658:701020:7098037098037110411239Methanothermus fervidus DSM 2088 chromosome, complete genome4fe-4S ferredoxin iron-sulfur binding domain protein5e-0962.4
NC_000916:1417981:1421167142116714221771011Methanothermobacter thermautotrophicus str. Delta H, completetungsten formylmethanofuran dehydrogenase, subunit F6e-0962
NC_003454:63500:1020681020681032251158Fusobacterium nucleatum subsp. nucleatum ATCC 25586, completeRNFB-related protein8e-0961.6
NC_019978:2260395:2286283228628322880851803Halobacteroides halobius DSM 5150, complete genomeNADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit2e-0860.5
NC_015320:967701:971293971293972057765Archaeoglobus veneficus SNP6 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur-binding domain-containing protein2e-0860.1
NC_003551:415803:428829428829429407579Methanopyrus kandleri AV19, complete genomeFerredoxin2e-0860.1
NC_014507:2479221:2480727248072724818901164Methanoplanus petrolearius DSM 11571 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain-containing protein2e-0860.1
NC_017096:1147441:116641311664131166700288Caldisericum exile AZM16c01, complete genomeputative electron transport complex protein RnfB2e-0860.1
NC_013156:154233:1542331542331553001068Methanocaldococcus fervens AG86, complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein3e-0859.7
NC_013790:485468:4936794936794947821104Methanobrevibacter ruminantium M1 chromosome, complete genometungsten formylmethanofuran dehydrogenase subunit F FwdF2e-0859.7
NC_015574:143000:146833146833147327495Methanobacterium sp. SWAN-1 chromosome, complete genomehelix-turn-helix domain-containing protein4e-0858.9
NC_013446:2655955:267383726738372674499663Comamonas testosteroni CNB-2, complete genomeelectron transport complex, RnfABCDGE type, B5e-0858.9
NC_000909:446364:455930455930456421492Methanocaldococcus jannaschii DSM 2661, complete genomepolyferredoxin (mvhB)5e-0858.9
NC_018876:2628966:264232026423202643258939Methanolobus psychrophilus R15 chromosome, complete genomeformylmethanofuran dehydrogenase, subunit F7e-0858.5
NC_016627:1485799:1516511151651115183041794Clostridium clariflavum DSM 19732 chromosome, complete genomeNADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit1e-0757.8
NC_014733:1857020:185702018570201857862843Methylovorus sp. MP688 chromosome, complete genomeelectron transport complex, rnfABCdge type, b subunit1e-0757.8
NC_014328:773095:7827417827417845401800Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeNADH dehydrogenase I subunit F1e-0757.4
NC_010644:485966:5097615097615111971437Elusimicrobium minutum Pei191, complete genomehydrogenase large subunit2e-0757
NC_000916:826614:842001842001842999999Methanothermobacter thermautotrophicus str. Delta H, completetungsten formylmethanofuran dehydrogenase, subunit F homolog2e-0757
NC_000909:446364:4563994563994576251227Methanocaldococcus jannaschii DSM 2661, complete genomepolyferredoxin2e-0757
NC_018870:427357:4339954339954357491755Thermacetogenium phaeum DSM 12270 chromosome, complete genomeNADH-quinone oxidoreductase 51 kDa subunit F2e-0757
NC_016048:1602500:1604790160479016066791890Oscillibacter valericigenes Sjm18-20, complete genomeputative uptake hydrogenase subunit HupB2e-0756.6
NC_019977:728922:7318547318547328761023Methanomethylovorans hollandica DSM 15978, complete genomeNADH:ubiquinone oxidoreductase chain I-like protein3e-0756.2
NC_015636:1061736:107414110741411074650510Methanothermococcus okinawensis IH1 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain-containing protein4e-0755.8
NC_014365:3123853:3140717314071731426331917Desulfarculus baarsii DSM 2075 chromosome, complete genomeNADH dehydrogenase (quinone)4e-0755.8
NC_015519:2605709:2615447261544726173241878Tepidanaerobacter sp. Re1 chromosome, complete genomeNADH dehydrogenase (quinone)6e-0755.5
NC_009617:385000:3941173941173956071491Clostridium beijerinckii NCIMB 8052 chromosome, complete genomeferredoxin hydrogenase6e-0755.5
NC_004663:107019:1149791149791168861908Bacteroides thetaiotaomicron VPI-5482, complete genomeNADH:ubiquinone oxidoreductase subunit6e-0755.5
NC_015216:2548057:255783325578332558282450Methanobacterium sp. AL-21 chromosome, complete genomehelix-turn-helix domain-containing protein7e-0755.1
NC_015389:1298689:1320798132079813223511554Coriobacterium glomerans PW2 chromosome, complete genomehydrogenase large subunit domain protein1e-0654.7
NC_014121:2330451:235749623574962358074579Enterobacter cloacae subsp. cloacae ATCC 13047 chromosome, completeelectron transport complex protein RnfB1e-0654.7
NC_015424:2836920:284989028498902850468579Aeromonas veronii B565 chromosome, complete genomeputative NADH:ubiquinone oxidoreductase subunit RnfB1e-0654.3
NC_000909:858840:864213864213864842630Methanocaldococcus jannaschii DSM 2661, complete genomepolyferredoxin (mvhB)1e-0654.3
NC_014537:663216:6715496715496752293681Vulcanisaeta distributa DSM 14429 chromosome, complete genomemethyl-viologen-reducing hydrogenase subunit delta1e-0654.3
NC_013203:472679:4744474744474760421596Atopobium parvulum DSM 20469, complete genomeFerredoxin hydrogenase1e-0654.3
NC_009348:2631759:264854926485492649112564Aeromonas salmonicida subsp. salmonicida A449, complete genomeelectron transport complex protein RnfB1e-0653.9
NC_009515:1409912:143475814347581435219462Methanobrevibacter smithii ATCC 35061, complete genometungsten formylmethanofuran dehydrogenase, subunit E, FwdE2e-0653.9
NC_007955:545000:5610465610465623561311Methanococcoides burtonii DSM 6242, complete genome4Fe-4S ferredoxin, iron-sulfur binding2e-0653.5
NC_010001:109893:1200331200331214871455Clostridium phytofermentans ISDg, complete genomeFerredoxin hydrogenase2e-0653.5
NC_008309:1155218:117394811739481174538591Haemophilus somnus 129PT, complete genomeelectron transport complex protein2e-0653.1
NC_014377:532816:5468405468405487171878Thermosediminibacter oceani DSM 16646 chromosome, complete genomeNADH dehydrogenase (quinone)3e-0653.1
NC_010519:1764261:177709717770971777687591Haemophilus somnus 2336 chromosome, complete genomeelectron transporter subunit RnfB3e-0653.1
NC_015563:3571682:359501835950183595734717Delftia sp. Cs1-4 chromosome, complete genomeRnfABCDGE type electron transport complex subunit B4e-0652.8
NC_004545:96422:120063120063120572510Buchnera aphidicola str. Bp (Baizongia pistaciae), complete genomeelectron transport complex protein RnfB5e-0652.4
NC_009706:830461:839370839370840332963Clostridium kluyveri DSM 555 chromosome, complete genomeNADH dehydrogenase-like protein4e-0652.4
NC_011837:830436:839345839345840307963Clostridium kluyveri NBRC 12016, complete genomehypothetical protein4e-0652.4
NC_015709:1459838:150893115089311509596666Zymomonas mobilis subsp. pomaceae ATCC 29192 chromosome, completeRnfABCDGE type electron transport complex subunit B4e-0652.4
NC_018870:2316499:237018823701882371063876Thermacetogenium phaeum DSM 12270 chromosome, complete genomecobyrinic acid a,c-diamide synthase6e-0652
NC_013887:245236:2770792770792782961218Methanocaldococcus sp. FS406-22 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein6e-0652
NC_016816:2508204:253005325300532530631579Pantoea ananatis LMG 5342, complete genomeRnfABCDGE type electron transport complex subunit B6e-0652
NC_013790:485468:493228493228493677450Methanobrevibacter ruminantium M1 chromosome, complete genometungsten formylmethanofuran dehydrogenase subunit H FwdH6e-0652
NC_010002:3980832:398247939824793983195717Delftia acidovorans SPH-1, complete genomeelectron transport complex, RnfABCDGE type, B subunit5e-0652
NC_015958:1983815:2002191200219120037321542Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genomehydrogenase large subunit domain-containing protein9e-0651.2
NC_010723:371741:3830613830613845451485Clostridium botulinum E3 str. Alaska E43, complete genomeiron-dependent hydrogenase9e-0651.2
NC_009464:300422:302331302331302747417Uncultured methanogenic archaeon RC-I, complete genome4(4Fe-4S) polyferredoxin9e-0651.2
NC_000916:1417981:142065014206501421150501Methanothermobacter thermautotrophicus str. Delta H, completetungsten formylmethanofuran dehydrogenase, subunit H9e-0651.2
NC_017187:325229:334461334461334937477Arcobacter butzleri ED-1, complete genomeferredoxin-type protein NapF1e-0551.2